Sillmann, Y, P Eber, A Baggio, B Freedman, C Liu, and F Guastaldi. 2025. “Unlocking Bone Growth: The Impact of 3D-Printed β-TCP Scaffold Pore Size on Osteogenic Differentiation in Dynamic Culture”. International Journal of Oral and Maxillofacial Surgery.
Abstract
Background: Autogenous bone grafts are the gold standard for reconstructing critical-sized bone defects in oral and maxillofacial surgery (OMS) but have limitations such as donor site morbidity. Bone tissue engineering (BTE) offers a promising alternative, with 3D-printing enabling precise scaffold design. The influence of scaffold architecture on osteogenesis, however, requires further exploration.
Aim: This study evaluates the impact of two 3D-printed β-tricalcium phosphate (β-TCP) scaffold architectures, with 500 µm and 1000 µm macropores, on cell proliferation, osteogenic differentiation, and ex vivo bone formation in a dynamic culture.