This research area harnesses the unique capabilities of nanomaterials to refine diagnostic imaging and open avenues for targeted treatment. By engineering nanoparticle contrast agents—such as functionalized tantalum oxide nanoparticles—the group can selectively bind to specific tissue biomarkers in cartilage. This approach not only improves the sensitivity and specificity of CT imaging but also enables the precise quantification of key biochemical components (like proteoglycans and collagen) that determine tissue mechanical properties. Ultimately, these advances facilitate “theranostic” applications, where the same nanoparticles could be used to both diagnose and deliver localized therapies in conditions such as osteoarthritis, paving the way for personalized, minimally invasive interventions.
