Weber, Griffin, Jay Shendure, David M Tanenbaum, George M Church, and Matthew Meyerson. 2002. “Identification of Foreign Gene Sequences by Transcript Filtering Against the Human Genome.”. Nature Genetics 30 (2): 141-2.
Abstract
We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries.