Nate is exploring the human response to heat stress using a custom-designed heat chamber. Working with Dustin Allen, Ph.D., at the Boston University Sargent College of Health & Rehabilitation Sciences, Nate is using metabolomics to test how the the kidney responds to exercise in high heat and humidity. The ultimate goal of the work is to help understand the pathogenesis of Mesoamerican Nephropathy, a kidney disease that affects mostly young men in Central America who do strenuous labor in tropical climates.