Publications

2008

Mahmood F, Matyal R, Maslow A, et al. Myocardial performance index is a predictor of outcome after abdominal aortic aneurysm repair.. J Cardiothorac Vasc Anesth. 2008;22(5):706-12. doi:10.1053/j.jvca.2008.04.006
OBJECTIVE: Perioperative measurement of the myocardial performance index (MPI) with transesophageal echocardiography in patients undergoing elective abdominal aortic aneurysm repair and its association with outcome. DESIGN: A prospective observational study. SETTING: A tertiary care university hospital. PARTICIPANTS: Patients undergoing elective abdominal aortic aneurysm repair. INTERVENTION: Perioperative transesophageal echocardiography. MEASUREMENTS: Fifty-one consecutive patients undergoing elective abdominal aortic aneurysm repair were enrolled in the study. The MPI was calculated by using pulse-wave Doppler from the midesophageal window and the deep transgastric position of the probe. In addition, diastolic function was measured as the slope of the transmitral flow propagation velocity, and ejection fraction was calculated as a measure of ventricular systolic function. Comparisons between subjects with uncomplicated versus adverse outcomes were made by using a Mann-Whitney U test. Comparison of the incidence of adverse outcome among subjects with normal and elevated MPIs was made by using a Fisher exact test. Statistical significance was set at p 0.05. RESULTS: It was possible to calculate MPI in all patients with transesophageal echocardiography perioperatively. Patients with adverse postoperative outcomes had an elevated MPI as compared with those without any adverse outcome (0.50 v 0.30, p 0.001). Also, an MPI of > or = 0.36 was associated with a statistically significant higher incidence of complications (congestive heart failure/prolonged intubation) (p 0.001). CONCLUSIONS: The MPI is an easily obtained echocardiographic measure of global ventricular performance, which can be measured perioperatively and may be useful as a prospective risk stratification index for patients undergoing elective abdominal aortic aneurysm surgery.

2007

Mahmood F, Matyal R, Subramaniam B, et al. Transmitral flow propagation velocity and assessment of diastolic function during abdominal aortic aneurysm repair.. J Cardiothorac Vasc Anesth. 2007;21(4):486-91. doi:10.1053/j.jvca.2007.01.023
INTRODUCTION: In the perioperative arena, pronounced changes in cardiac loading conditions can make assessment of diastolic parameters difficult. A number of Doppler techniques have been introduced to assess perioperative diastolic function. OBJECTIVES: To compare transmitral flow propagation velocity (Vp) with other pulse-wave Doppler echocardiographic assessments of diastolic function in patients undergoing elective abdominal aortic aneurysm (AAA) resection. DESIGN: A prospective observational study. STUDY SUBJECTS: Forty-five consecutive patients undergoing elective AAA repair under general anesthesia. METHODS: Transesophageal echocardiographic examination was performed before, during, and after removal of the aortic cross-clamp (AXC). Diastolic function was categorized on the basis of the ratio of transmitral pulse-wave Doppler (PWD) into early (E) and late (A) waves and their ratio (E/A), deceleration time, and use of pulmonary venous inflow patterns to identify pseudonormal pattern. Subjects were then assessed by using the Canadian Consensus Guidelines (CCG) and on the basis of transmitral flow Vp. The correlation among methods for diagnosis of diastolic dysfunction and pseudonormal pattern was examined. Diastolic function over each of the 3 periods to assess changes during AXC was examined. RESULTS: Data analysis was completed in 35 patients. The authors found excellent correlation between E/A ratio and Vp for diagnosis of diastolic dysfunction (24/25 cases) and a pseudonormal pattern (18/20 cases). The CCG methodology identified fewer cases of diastolic dysfunction than Vp (p = 0.003). The evaluation using CCG methodology could not be categorized in 15% of cases. The incidence of diastolic dysfunction increased during placement of AXC with both Vp and CCG (p 0.05) but not by E/A ratio, and returned to baseline after removal of the AXC. Good correlation was found among all 3 methods (p 0.05 and r > 0.5 for all). CONCLUSION: Vp assessment identified the majority (93%) of cases of diastolic dysfunction identified by traditional methods. Furthermore, the incidence of diastolic dysfunction increased with application of the AXC but returned to baseline after removal.

2006

Matyal R, Mahmood F, Panzica P, et al. Inadvertent placement of a flow-directed pulmonary artery catheter in the coronary sinus, detected by transesophageal echocardiography.. Anesth Analg. 2006;102(2):363-5. doi:10.1213/01.ane.0000195340.65783.81
We report a case in which flow-directed placement of the pulmonary artery catheter led to its inadvertent placement in the coronary sinus, in the absence of congenital anomalies. Incorrect placement was diagnosed by use of the transesophageal echocardiography. If unrecognized, the catheter might have provided misleading information and led to mismanagement of the patient.

2005