Gharahkhani P, Jorgenson E, Hysi P, Khawaja A, Pendergrass S, Han X, Ong JS, Hewitt A, Segrè A, Rouhana J, Hamel A, Igo R, Choquet H, Qassim A, Josyula N, Cooke Bailey J, Bonnemaijer P, Iglesias A, Siggs O, Young T, Vitart V, Thiadens A, Karjalainen J, Uebe S, Melles R, Nair S, Luben R, Simcoe M, Amersinghe N, Cree A, Höhn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN, NEIGHBORHOOD Consortium, ANZRAG Consortium, BioBank Japan Project, FinnGen study, Consortium UBEV, GIGA Study Group, 23andMe Research Team, Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton M, Martin N, Ashaye A, Olawoye O, Williams S, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster P, Khaw P, Morgan J, Strouthidis N, Kraft P, Kang J, Pang CP, Pasutto F, Mitchell P, Lotery A, Palotie A, Duijn C, Haines J, Hammond C, Pasquale L, Klaver C, Hauser M, Khor CC, Mackey D, Kubo M, Cheng CY, Craig J, Macgregor S, Wiggs J. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun. 2021;12(1):1258.
Abstract
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates.
Last updated on 03/06/2023