Logue, M., Rooij, S. J. H., Dennis, E. L., Davis, S. L., Hayes, J., Stevens, J. S., Densmore, M., Haswell, C. C., Ipser, J., Koch, S. B. J., Korgaonkar, M., Lebois, L. A. M., Peverill, M., Baker, J. T., Boedhoe, P. S. W., Frijling, J. L., Gruber, S. A., Harpaz-Rotem, I., Jahanshad, N., … Morey, R. A. (2018). Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biol Psychiatry, 83, 244-253.
NOTES
1873-2402Logue, Mark Wvan Rooij, Sanne J HDennis, Emily LDavis, Sarah LHayes, Jasmeet PStevens, Jennifer SDensmore, MariaHaswell, Courtney CIpser, JonathanKoch, Saskia B JKorgaonkar, MayureshLebois, Lauren A MPeverill, MatthewBaker, Justin TBoedhoe, Premika S WFrijling, Jessie LGruber, Staci AHarpaz-Rotem, IlanJahanshad, NedaKoopowitz, SheriLevy, IfatNawijn, LauraO'Connor, LaurenOlff, MirandaSalat, David HSheridan, Margaret ASpielberg, Jeffrey Mvan Zuiden, MirjamWinternitz, Sherry RWolff, Jonathan DWolf, Erika JWang, XinWrocklage, KristenAbdallah, Chadi GBryant, Richard AGeuze, ElbertJovanovic, TanjaKaufman, Milissa LKing, Anthony PKrystal, John HLagopoulos, JimBennett, MaxwellLanius, RuthLiberzon, IsraelMcGlinchey, Regina EMcLaughlin, Katie AMilberg, William PMiller, Mark WRessler, Kerry JVeltman, Dick JStein, Dan JThomaes, KathleenThompson, Paul MMorey, Rajendra AR01 MH071537/MH/NIMH NIH HHS/United StatesU54 NS100064/NS/NINDS NIH HHS/United StatesK23 MH073091/MH/NIMH NIH HHS/United StatesR01 MH106482/MH/NIMH NIH HHS/United StatesU01 MH109536/MH/NIMH NIH HHS/United StatesR01 MH110483/MH/NIMH NIH HHS/United StatesUL1 TR000454/TR/NCATS NIH HHS/United StatesUL1 TR002378/TR/NCATS NIH HHS/United StatesK01 MH092526/MH/NIMH NIH HHS/United StatesR01 MH106595/MH/NIMH NIH HHS/United StatesP41 EB015922/EB/NIBIB NIH HHS/United StatesI01 CX000120/CX/CSRD VA/United StatesR56 MH071537/MH/NIMH NIH HHS/United StatesI01 RX000389/RX/RRD VA/United StatesI01 BX003477/BX/BLRD VA/United StatesF32 MH109274/MH/NIMH NIH HHS/United StatesR01 MH103291/MH/NIMH NIH HHS/United StatesR21 MH098212/MH/NIMH NIH HHS/United StatesR01 NS086885/NS/NINDS NIH HHS/United StatesI01 CX000748/CX/CSRD VA/United StatesR21 MH112956/MH/NIMH NIH HHS/United StatesM01 RR000039/RR/NCRR NIH HHS/United StatesR01 MH111671/MH/NIMH NIH HHS/United StatesF32 MH101976/MH/NIMH NIH HHS/United StatesU54 EB020403/EB/NIBIB NIH HHS/United StatesCIHR/CanadaR21 MH102834/MH/NIMH NIH HHS/United StatesR01 AG050595/AG/NIA NIH HHS/United StatesJournal ArticleMeta-AnalysisMulticenter StudyResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Biol Psychiatry. 2018 Feb 1;83(3):244-253. doi: 10.1016/j.biopsych.2017.09.006. Epub 2017 Sep 20.
Abstract
BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. METHODS: We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. RESULTS: In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = -0.17, p = .00054), and smaller amygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p .0063). CONCLUSIONS: Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.
Last updated on 03/06/2023