Adamopoulos, Iannis E, and Vijay Kuchroo. (2023) 2023. “IL-17A and IL-17F in Tissue Homeostasis, Inflammation and Regeneration.”. Nature Reviews. Rheumatology 19 (9): 535-36. https://doi.org/10.1038/s41584-023-01004-5.
IL-17 signalling regulates both protective and harmful immune responses; therefore, its complete inhibition can have adverse effects. Detailed consideration and fine-tuning of IL-17-inhibition strategies is needed to selectively regulate disease outcomes.