1. Home
  2. Key Publications

Key Publications

  1. Auger C, Kajimura S. Adipose Tissue Remodeling in Pathophysiology. Annu Rev Pathol. 2022 Sep 7;. doi: 10.1146/annurev-pathol-042220-023633.
    Abstract [Link]
     
  2. Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S. Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature. 2022 Sep;609(7925):151-158. doi: 10.1038/s41586-022-05067-4.
    Abstract [Link]
     
  3. Yook JS, Kajimura S. Is thermogenesis really needed for brown adipose tissue-mediated metabolic benefit? J Clin Invest. 2022 May 2;132(9):e159296. doi: 10.1172/JCI159296. PMID: 35499086; PMCID: PMC9057615.
    Abstract [Link]
     
  4. Oguri Y, Shinoda K, Kim H, Alba D, Bolus WR, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen C, Cheang RT, Tsujino KR, Greiner VJ, McManus MT, Koliwad S, Spiegelman BM, and Kajimura S. CD81 controls beige progenitor cell growth and energy balance through Integrin-FAK signaling. Cell 2020; Jun 26: S0092-8674(20)30753-4. PMID: 32615086. PMC7415677.
    Abstract [Link]
     
  5. Yoneshiro, T., Wang, Q., Tajima, K., Matsushita, M., Maki, H., Igarashi, K., Dai, Z., White, P. J., McGarrah, R. W., Ilkayeva, O., Deleye, Y., Oguri, Y., Kuroda, M., Ikeda, K., Li, H., Ueno, A., Ohishi, M., Ishikawa, T., Kim, K., Chen, Y., Sponton, C. H., Pradhan, R. N., Majd, H., Greiner, V. J., Yoneshiro, M., Brown, Z., Chondronikola, M., Takahashi, H., Goto, T., Kawada, T., Sidossis, L., Szoka, F. C., McManus, M. T., Saito, M., Soga, T., & Kajimura S. (2019) BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature (Article) 572(7771):614-619. PMC6715529 [Research highlight in NEJM 2019, Nature Metabolism 2019, Nature Reviews Endocrinology 2019, TIME etc.]
    Abstract [Link]
     
  6. Chen Y., Ikeda K., Yoneshiro T., Scaramozza, A., Tajima, K., Wang, Q., Kim K., Shinoda K., Henrique- Sponton C., Brown Z., Brack A., & Kajimura S. (2019) Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature (Article) 565(7738):180-185. PMC6328316 [Research highlight in Nature 2019, Nature Reviews Endocrinology 2019, Faculty1000]
    Abstract [Link]
     
  7. Tajima K., Ikeda K., Chang H.Y., Chang C.H., Yoneshiro T., Oguri Y., Jun H., Wu J., Ishihama Y., & Kajimura S. (2019). Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nature Metabolism 1, 886-898.
    Abstract [Link]
     
  8. Hasegawa Y, Ikeda K, Chen Y, Alba D, Stifler D, Shinoda K, Hosono T, Maretich P, Yang Y, Ishigaki Y, Chi J, Cohen P, Koliwad S, & Kajimura S. (2018) Repression of adipose tissue fibrosis through a PRDM16-GTF2IRD1 complex improves systemic glucose homeostasis. Cell Metabolism 27(1), 180-194. PMC5727902 [Selected in Faculty1000]
    Abstract [Link]
     
  9. Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Lu, X, Maretich P, Ajuwon KM, Soga T, & Kajimura S. (2017). UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nature Medicine (12):1454-1465PMC5727902 [Research highlight in Nature Medicine 2017; Nature Reviews Endocrinology 2017; Cell Metabolism; 2017, Science Signaling 2017, TIME, Faculty1000]
    Abstract [Link]
     
  10. Altshuler-Keylin S, Shinoda K, Hong H, Hasegawa Y, Ikeda K, Yang Y, Perera RM, Debnath J, & Kajimura S. (2016) Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance. Cell Metabolism 24(3):402-19. PMC5023491 [Research highlight in Cell Metabolism 2016; Nature Reviews Endocrinology 2016]
    Abstract [Link]
     
  11. Shinoda K, Ohyama K, Hasegawa Y, Chang H-Y, Ogura M, Sato A, Hong H, Hosono T, Sharp LZ, Scheel DW, Graham M, Ishihama Y, & Kajimura S. (2015) Phosphoproteomics Identifies CK2 as a negative regulator of beige adipocyte thermogenesis and energy expenditure.  Cell Metabolism 22(6):997-1008. [Research highlight in Cell Metabolism 2015]
    Abstract [Link]
     
  12. Shinoda K, Luijten IHN, Hasegawa Y, Hong H, Sonne SB, Xue R, Chondronikola M, Kim M, Cypess AM, Tseng Y, Nedergaard J, Sidossis LS, & Kajimura S. (2015). Genetic and functional characterization of clonally-derived adult human brown adipocytes. Nature Medicine 21(4):389-94. PMC4427356 [Research highlight in Nature Medicine 2015]
    Abstract [Link]
     
  13. Ohno H, Shinoda K, Ohyama K, Sharp LZ, & Kajimura S.  (2013) EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 504(7478):163-67. PMC3855638 [Research highlight in Cell Metabolism 2014, Selected in Faculty1000, NIH director’s blog]
    Abstract [Link]
     
  14. Ohno H., Shinoda K., Spiegelman B.M. & Kajimura S.  (2012) PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metabolism 15(3), 395-404.PMC3410936    
    Abstract [Link]