Nardella, Caterina, John G Clohessy, Andrea Alimonti, and Pier Paolo Pandolfi. 2011. “Pro-Senescence Therapy for Cancer Treatment.”. Nature Reviews. Cancer 11 (7): 503-11.
Abstract
Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.