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4287 results found

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.

Publication: Journal Article

Chen, Ming, Jiangwen Zhang, Katia Sampieri, John G Clohessy, Lourdes Mendez, Enrique Gonzalez-Billalabeitia, Xue-Song Liu, et al. 2018. “An Aberrant SREBP-Dependent Lipogenic Program Promotes Metastatic Prostate Cancer.”. Nature Genetics 50 (2): 206-18.

Characterization and analysis of the composition and dynamics of the mammalian riboproteome.

Publication: Journal Article

Reschke, Markus, John G Clohessy, Nina Seitzer, Daniel P Goldstein, Susanne B Breitkopf, Daniel B Schmolze, Ugo Ala, John M Asara, Andrew H Beck, and Pier Paolo Pandolfi. 2013. “Characterization and Analysis of the Composition and Dynamics of the Mammalian Riboproteome.”. Cell Reports 4 (6): 1276-87.

Found in translation of mTOR signaling.

Publication: Journal Article

Clohessy, John G, Markus Reschke, and Pier Paolo Pandolfi. 2012. “Found in Translation of MTOR Signaling.”. Cell Research 22 (9): 1315-8.

Pro-senescence therapy for cancer treatment.

Publication: Journal Article

Nardella, Caterina, John G Clohessy, Andrea Alimonti, and Pier Paolo Pandolfi. 2011. “Pro-Senescence Therapy for Cancer Treatment.”. Nature Reviews. Cancer 11 (7): 503-11.

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.

Publication: Journal Article

Cheng, Ke, Paolo Sportoletti, Keisuke Ito, John G Clohessy, Julie Teruya-Feldstein, Jeffery L Kutok, and Pier Paolo Pandolfi. 2010. “The Cytoplasmic NPM Mutant Induces Myeloproliferation in a Transgenic Mouse Model.”. Blood 115 (16): 3341-5.

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.

Publication: Journal Article

Sportoletti, Paolo, Silvia Grisendi, Samia M Majid, Ke Cheng, John G Clohessy, Agnes Viale, Julie Teruya-Feldstein, and Pier Paolo Pandolfi. 2008. “Npm1 Is a Haploinsufficient Suppressor of Myeloid and Lymphoid Malignancies in the Mouse.”. Blood 111 (7): 3859-62.

In Vitro Target Validation

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Target validation of agents or combinations of agents in cell culture in one or more murine and human tumor cell lines or mouse embryonic fibroblasts (MEFs) of various genotypes (see below). Use of several different assays depending upon the agent and type of information sought. Availability of an...

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.

Publication: Journal Article

Lee, Jennifer, Kerry Wellenstein, Ali Rahnavard, Andrew T Nelson, Marlena M Holter, Bethany P Cummings, Vladimir Yeliseyev, et al. 2024. “Beneficial Metabolic Effects of PAHSAs Depend on the Gut Microbiota in Diet-Induced Obese Mice But Not in Chow-Fed Mice.”. Proceedings of the National Academy of Sciences of the United States of America 121 (28): e2318691121.

Xiaowen Liu, PhD

Person: Director of Biomarker and Metabolism Research Core, Assistant Professor of Emergency Medicine, Harvard Medical School

Dr. Liu’s research is focused on human nutritional and metabolic dysfunction in the critically ill patients. After completing 6 years of the Interdepartmental Graduate Program in Nutritional Sciences and statistics in university of Wisconsin- Madison, and 3.5 years of postdoctoral training in...

Prevalence and Control of Diabetes Among US Adults, 2013 to 2023

Publication: Journal Article

Inoue, Kosuke, Michael Liu, Rahul Aggarwal, Lucas X Marinacci, and Rishi K Wadhera. 2025. “Prevalence and Control of Diabetes Among US Adults, 2013 to 2023”. JAMA.