Developmental origin of fat: tracking obesity to its source
Gesta, Stephane, Yu-Hua Tseng, and Ronald Kahn. 2007. “Developmental Origin of Fat: Tracking Obesity to Its Source”. Cell 131 (2): 242-56.
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IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance
Murata, Yusuke, Kaku Tsuruzoe, Junji Kawashima, Noboru Furukawa, Tatsuya Kondo, Hiroyuki Motoshima, Motoyuki Igata, et al. 2007. “IRS-1 Transgenic Mice Show Increased Epididymal Fat Mass and Insulin Resistance”. Biochem Biophys Res Commun 364 (2): 301-7.
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice
Cohen, Shmuel, Efi Kokkotou, Sudha Biddinger, Tatsuya Kondo, Rolf Gebhardt, Juergen Kratzsch, Christos Mantzoros, and Ronald Kahn. 2007. “High Circulating Leptin Receptors With Normal Leptin Sensitivity in Liver-Specific Insulin Receptor Knock-Out (LIRKO) Mice”. J Biol Chem 282 (32): 23672-8.
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance
Xue, Bingzhong, Young-Bum Kim, Anna Lee, Elena Toschi, Susan Bonner-Weir, Ronald Kahn, Benjamin Neel, and Barbara Kahn. 2007. “Protein-Tyrosine Phosphatase 1B Deficiency Reduces Insulin Resistance and the Diabetic Phenotype in Mice With Polygenic Insulin Resistance”. J Biol Chem 282 (33): 23829-40.
p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis
Winnay, Jonathon, Ercument Dirice, Chong Wee Liew, Rohit Kulkarni, and Ronald Kahn. 2014. “P85α Deficiency Protects β-Cells from Endoplasmic Reticulum Stress-Induced Apoptosis”. Proc Natl Acad Sci U S A 111 (3): 1192-7.
Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy
Mori, Marcelo, Thomas Thomou, Jeremie Boucher, Kevin Lee, Susanna Lallukka, Jason Kim, Martin Torriani, et al. 2014. “Altered MiRNA Processing Disrupts Brown/White Adipocyte Determination and Associates With Lipodystrophy”. J Clin Invest 124 (8): 3339-51.
Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling
Boucher, Jeremie, Marcelo Mori, Kevin Lee, Graham Smyth, Chong Wee Liew, Yazmin Macotela, Michael Rourk, Matthias Bluher, Steven Russell, and Ronald Kahn. 2012. “Impaired Thermogenesis and Adipose Tissue Development in Mice With Fat-Specific Disruption of Insulin and IGF-1 Signalling”. Nat Commun 3: 902.
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism
Lee, Kevin, Manvendra Singh, Siegfried Ussar, Petra Wetzel, Michael Hirshman, Laurie Goodyear, Andreas Kispert, and Ronald Kahn. 2015. “Tbx15 Controls Skeletal Muscle Fibre-Type Determination and Muscle Metabolism”. Nat Commun 6: 8054.
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
Cai, Weikang, Masaji Sakaguichi, Andre Kleinridders, Gonzalo Gonzales-Del Pino, Jonathan Dreyfus, Brian O’Neill, Alfred Ramirez, et al. 2017. “Domain-Dependent Effects of Insulin and IGF-1 Receptors on Signalling and Gene Expression”. Nature Communications 8 (14892).
Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites
Fujisaka, Shiho, Julian Avila-Pacheco, Marion Soto, Aleksandar Kostic, Jonathan Dreyfuss, Hui Pan, Siegfried Ussar, et al. 2018. “Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites”. Cell Rep 22 (11): 3072-86.