Novel biomarkers and pathways in type 2 diabetes risk
Ngo, Debby, Mark Benson, Jonathan Long, Zsu-Zsu Chen, Ruiqi Wang, Anjali K. Nath, Michelle Keyes, et al. 2021. “Novel Biomarkers and Pathways in Type 2 Diabetes Risk”. JCI Insight.
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CV
Research
Our goal is to develop small molecules that modulate cardiometabolic disease-associated genes. To achieve this objective, our lab focuses on the following activities: genetic discovery in human cohorts, genome editing in zebrafish and human cell lines, mass spectrometry-based metabolite profiling...
A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function
Giordano, Gerber, Williams, VanBruggen, Bunting, Ruiz-Lozano, Gu, et al. 2001. “A Cardiac Myocyte Vascular Endothelial Growth Factor Paracrine Pathway Is Required to Maintain Cardiac Function”. Proc Natl Acad Sci U S A 98 (10): 5780-5.
Cell organization, growth, and neural and cardiac development require αII-spectrin
Stankewich, Michael, Carol Cianci, Paul Stabach, Lan Ji, Anjali Nath, and Jon Morrow. 2011. “Cell Organization, Growth, and Neural and Cardiac Development Require αII-Spectrin”. J Cell Sci 124 (Pt 23): 3956-66.
Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1
Ambrosini, Grazia, Anjali Nath, Rocio Sierra-Honigmann, and Jaime Flores-Riveros. 2002. “Transcriptional Activation of the Human Leptin Gene in Response to Hypoxia. Involvement of Hypoxia-Inducible Factor 1”. J Biol Chem 277 (37): 34601-9.
Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish
Nath, Anjali K., Junyan Ma, Zsu-Zsu Chen, Zhuyun Li, Maria Carmen Vitery, Michelle L. Kelley, Randall T. Peterson, Robert E. Gerszten, and Jing-Ruey J. Yeh. 2020. “Genetic Deletion of Gpr27 Alters Acylcarnitine Metabolism, Insulin Sensitivity, and Glucose Homeostasis in Zebrafish”. FASEB 34: 1546-57.
Top2a promotes the development of social behavior via PRC2 and H3K27me3
Y, Geng, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, et al. 2022. “Top2a Promotes the Development of Social Behavior via PRC2 and H3K27me3”. Science Advances 8 (47).
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We are part of a dynamic research consortium that leverages cutting edge multiomics technologies and collaborates with colleagues across the nation. Together, we are a highly collaborative team of biologists, chemists, physicians, and computational scientists who are committed to advancing the...