Search

Search results

74 results found

Funding

Page

R01; National Institute of Neurological Disorders and Stroke Targeting the FBXW7/PGC1 Pathway as a Therapeutic Strategy for Parkinson's Disease Principal Investigator(s): David K Simon, Wenyi Wei PGC-1alpha regulates mitochondrial synthesis, and a deficiency PGC-1alpha may play a role in Parkinson’s...

Pgc-1α overexpression downregulates pitx3 and increases susceptibility to MPTP toxicity associated with decreased bdnf

Publication: Journal Article

Clark, J, JM Silvaggi, T Kiselak, K Zheng, E Clore, Y Dai, CE Bass, and DK Simon. 2012. “Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated With Decreased Bdnf”. PLoS ONE.

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

Publication: Journal Article

St-Pierre, Julie, Stavit Drori, Marc Uldry, Jessica M Silvaggi, James Rhee, Sibylle Jäger, Christoph Handschin, et al. 2006. “Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators”. Cell.

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

Publication: Journal Article

Clark, Joanne, Elizabeth L Clore, Kangni Zheng, Anthony Adame, Eliezer Masliah, and David K Simon. 2010. “Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice”. PLOS ONE.

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice

Publication: Government Report

Dai, Ying, Kangni Zheng, Joanne Clark, Russell H Swerdlow, Stefan M Pulst, James P Sutton, Leslie A Shinobu, and David K Simon. 2014. “Somatic Mitochondrial DNA Mutations Do Not Increase Neuronal Vulnerability to MPTP in Young POLG Mutator Mice.”

Tincidunt tortor aliquam nulla facilisi cras fermentum odio eu feugiat

Blog: May 16, 2023

Lectus nulla at volutpat diam ut. Mattis molestie a iaculis at erat pellentesque adipiscing. Felis imperdiet proin fermentum leo vel orci. Malesuada bibendum arcu vitae elementum curabitur. Turpis cursus in hac habitasse platea dictumst quisque sagittis purus. Voluptas quas qui minima id in...

Aut Molestiae Consectetur

Page

Quis autem repudiandae consequatur illo doloribus ratione. Omnis amet aut vitae ad accusamus. Tempore Quia Ut Ullam Nihil Aspernatur Eos. Debitis omnis ut dolore excepturi vel doloremque odit provident. Exercitationem maxime sit. Sapiente temporibus et magnam facilis impedit accusantium deserunt...

Postdoctoral fellow Dr. Michele Persico presents his work on 2a in vitro at the American Academy of Neurology Annual Meeting

News: April 16, 2024

Press release in BIDMC News

News: November 14, 2023

"Researchers Halt Progression in Parkinson's Disease Mouse Model" discussed in BIDMC press release Jacqueline Mitchell reports on the Simon Lab's contributions to a deeper understanding of the mechanisms underlying Parkinson's Disease and the best novel targets to investigate potential treatments...

Postdoctoral fellow Dr. Michele Persico (currently at Emory University) presented our work on VPS35 at the American Academy of Neurology Annual Meeting (AANAM) 2023.

News: April 27, 2023