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Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation

Publication: Journal Article

McGettrick, Aileen, Edward Feener, and Ronald Kahn. 2005. “Human Insulin Receptor Substrate-1 (IRS-1) Polymorphism G972R Causes IRS-1 to Associate With the Insulin Receptor and Inhibit Receptor Autophosphorylation”. J Biol Chem 280 (8): 6441-6.

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Tyrosine-specific protein kinase activity is associated with the purified insulin receptor

Publication: Journal Article

Kasuga, Fujita-Yamaguchi, Blithe, and Kahn. 1983. “Tyrosine-Specific Protein Kinase Activity Is Associated With the Purified Insulin Receptor”. Proc Natl Acad Sci U S A 80 (8): 2137-41.

Cultured quail neural crest cells attain competence for terminal differentiation into melanocytes before competence to terminal differentiation into adrenergic neurons

Publication: Journal Article

Kahn, and Sieber-Blum. 1983. “Cultured Quail Neural Crest Cells Attain Competence for Terminal Differentiation into Melanocytes before Competence to Terminal Differentiation into Adrenergic Neurons”. Dev Biol 95 (1): 232-8.

Insulin binding and activation of glycogen synthase in fibroblasts from Type 1 (insulin-dependent) diabetic patients

Publication: Journal Article

Podskalny, and Kahn. 1982. “Insulin Binding and Activation of Glycogen Synthase in Fibroblasts from Type 1 (insulin-Dependent) Diabetic Patients”. Diabetologia 23 (5): 431-5.

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine

Publication: Journal Article

Kasuga, Zick, Blith, Karlsson, Haring, and Kahn. 1982. “Insulin Stimulation of Phosphorylation of the Beta Subunit of the Insulin Receptor. Formation of Both Phosphoserine and Phosphotyrosine”. J Biol Chem 257 (17): 9891-4.

FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy.

Publication: Journal Article

BT, O’Neill, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, et al. 2019. “FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy.”. Diabetes 68 (3): 556-70.

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.

Publication: Journal Article

M, Sakaguchi, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, et al. 2019. “FoxK1 and FoxK2 in Insulin Regulation of Cellular and Mitochondrial Metabolism.”. Nature Communications 10 (1): 1582.

Developmental and functional heterogeneity of white adipocytes within a single fat depot.

Publication: Journal Article

KY, Lee, Luong Q, Sharma R, Dreyfuss JM, Ussar S, and Kahn CR. 2019. “Developmental and Functional Heterogeneity of White Adipocytes Within a Single Fat Depot.”. EMBO Journal 38 (3).

Wenqiang Chen

Person: Research Fellow

Dr. Wenqiang Chen is currently working as a post-doctoral research fellow in Ronald Kahn's lab at the Joslin Diabetes Center/Harvard Medical School. His research primarily focuses on how diabetes affects normal brain function related to reward and cognition;thus he aims to illuminate the interaction...