Effects of insulin-sensitising agents in mice with hepatic insulin resistance
Cohen, Tseng, Michael, and Kahn. 2004. “Effects of Insulin-Sensitising Agents in Mice With Hepatic Insulin Resistance”. Diabetologia 47 (3): 407-11.
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p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
Chen, Dong, Franck Mauvais-Jarvis, Matthias Bluher, Simon Fisher, Alison Jozsi, Laurie Goodyear, Kohjiro Ueki, and Ronald Kahn. 2004. “P50alpha/P55alpha Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity”. Mol Cell Biol 24 (1): 320-9.
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
Otani, Kenichi, Rohit Kulkarni, Aaron Baldwin, Jan Krutzfeldt, Kohjiro Ueki, Markus Stoffel, Ronald Kahn, and Kenneth Polonsky. 2004. “Reduced Beta-Cell Mass and Altered Glucose Sensing Impair Insulin-Secretory Function in BetaIRKO Mice”. Am J Physiol Endocrinol Metab 286 (1): E41-9.
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
Rosen, Evan, Rohit Kulkarni, Pasha Sarraf, Umut Ozcan, Terumasa Okada, Chung-Hsin Hsu, Daniel Eisenman, et al. 2003. “Targeted Elimination of Peroxisome Proliferator-Activated Receptor Gamma in Beta Cells Leads to Abnormalities in Islet Mass Without Compromising Glucose Homeostasis”. Mol Cell Biol 23 (20): 7222-9.
Role of Foxa-2 in adipocyte metabolism and differentiation
Wolfrum, Christian, David Shih, Satoru Kuwajima, Andrew Norris, Ronald Kahn, and Markus Stoffel. 2003. “Role of Foxa-2 in Adipocyte Metabolism and Differentiation”. J Clin Invest 112 (3): 345-56.
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Patti, Mary Elizabeth, Atul Butte, Sarah Crunkhorn, Kenneth Cusi, Rachele Berria, Sangeeta Kashyap, Yoshinori Miyazaki, et al. 2003. “Coordinated Reduction of Genes of Oxidative Metabolism in Humans With Insulin Resistance and Diabetes: Potential Role of PGC1 and NRF1”. Proc Natl Acad Sci U S A 100 (14): 8466-71.
Bi-directional regulation of brown fat adipogenesis by the insulin receptor
Entingh, Amelia, Cullen Taniguchi, and Ronald Kahn. 2003. “Bi-Directional Regulation of Brown Fat Adipogenesis by the Insulin Receptor”. J Biol Chem 278 (35): 33377-83.
Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes
Valverde, Angela, Monica Arribas, Cecilia Mur, Paloma Navarro, Sebastián Pons, Anne-Marie Cassard-Doulcier, Ronald Kahn, and Manuel Benito. 2003. “Insulin-Induced Up-Regulated Uncoupling Protein-1 Expression Is Mediated by Insulin Receptor Substrate 1 through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Fetal Brown Adipocytes”. J Biol Chem 278 (12): 10221-31.
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice
Laustsen, Palle, Dodson Michael, Barbara Crute, Shmuel Cohen, Kohjiro Ueki, Rohit Kulkarni, Susanna Keller, Gustav Lienhard, and Ronald Kahn. 2002. “Lipoatrophic Diabetes in Irs1(-/-)/Irs3(-/-) Double Knockout Mice”. Genes Dev 16 (24): 3213-22.
Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes
Shirakami, Toyonaga, Tsuruzoe, Shirotani, Matsumoto, Yoshizato, Kawashima, et al. 2002. “Heterozygous Knockout of the IRS-1 Gene in Mice Enhances Obesity-Linked Insulin Resistance: A Possible Model for the Development of Type 2 Diabetes”. J Endocrinol 174 (2): 309-19.