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588 results found

Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor

Publication: Journal Article

King, Kahn, and Heldin. 1983. “Sharing of Biological Effect and Receptors Between Guinea Pig Insulin and Platelet-Derived Growth Factor”. Proc Natl Acad Sci U S A 80 (5): 1308-12.

Suppression of catecholamine and melanin synthesis and promotion of cholinergic differentiation of quail neural crest cells by heart cell conditioned medium

Publication: Journal Article

Sieber-Blum, and Kahn. 1982. “Suppression of Catecholamine and Melanin Synthesis and Promotion of Cholinergic Differentiation of Quail Neural Crest Cells by Heart Cell Conditioned Medium”. Stem Cells 2 (6): 344-53.

Insulin receptor phosphorylation in intact adipocytes and in a cell-free system

Publication: Journal Article

Haring, Kasuga, and Kahn. 1982. “Insulin Receptor Phosphorylation in Intact Adipocytes and in a Cell-Free System”. Biochem Biophys Res Commun 108 (4): 1538-45.

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.

Publication: Journal Article

M, Soto, Herzog C, Pacheco JA, Fujisaka S, Bullock K, Clish CB, and Kahn CR. 2018. “Gut Microbiota Modulate Neurobehavior through Changes in Brain Insulin Sensitivity and Metabolism.”. Molecular Psyquiatry 23 (12): 2287-2301.

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.

Publication: Journal Article

M, Soto, Cai W, Konishi M, and Kahn CR. 2019. “Insulin Signaling in the Hippocampus and Amygdala Regulates Metabolism and Neurobehavior.”. Proc Natl Acad Sci U S A 116 (13): 6379-84.

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.

Publication: Journal Article

TM, Batista, Garcia-Martin R, Cai W, Konishi M, O’Neill BT, Sakaguchi M, Kim JH, Jung DY, Kim JK, and Kahn CR. 2019. “Multi-Dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.”. Cell Reports 26 (12): 3429-43.

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.

Publication: Journal Article

G, Wang, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, and Kahn CR. 2019. “Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.”. Molecular Cell S1097-2765 (19): 30225-4.

Research

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The Kahn Lab is investigating the mechanism of insulin action and its alterations in insulin resistant states, including type 2 diabetes, obesity and metabolic syndrome. There are 3 major areas of research: 1) Insulin action and insulin resistance. In this area we have projects focusing on the...

Insulin action - Mechanisms of insulin resistance

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Differential signaling by insulin and IGF-1 receptors Differences in downstream signaling (IRS proteins/PI 3-kinase) Signaling by unoccupied insulin receptor Cellular and whole animal analysis using KO and KI mice Signaling in unusual tissues, e.g. the gut and brain

Prof C. Ronald Kahn

Person: Professor at Harvard Medical School

C. Ronald Kahn is a world recognized expert in diabetes and obesity research, as well as a preeminent investigator in the area of insulin signal transduction and mechanisms of altered signaling in diabetes and metabolic disease. Dr. Kahn is Senior Investigator, Head of the Section on Integrative...