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65 results found

Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer.

Publication: Journal Article

Montanaro, L, M Brigotti, J Clohessy, S Barbieri, C Ceccarelli, D Santini, M Taffurelli, et al. 2006. “Dyskerin Expression Influences the Level of Ribosomal RNA Pseudo-Uridylation and Telomerase RNA Component in Human Breast Cancer.”. The Journal of Pathology 210 (1): 10-8.

From Mouse to Human: History

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APL as a Novel Paradigm for Experimental Therapeutics Acute promyelocytic leukemia (APL) is associated with the accumulation in the bone marrow of tumor cells with promyelocytic features and the invariable association with specific reciprocal chromosomal translocations involving the retinoic acid...

Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs.

Publication: Journal Article

Zhang, Yang, Tuan M Nguyen, Xiao-Ou Zhang, Limei Wang, Tin Phan, John G Clohessy, and Pier Paolo Pandolfi. 2021. “Optimized RNA-Targeting CRISPR/Cas13d Technology Outperforms ShRNA in Identifying Functional CircRNAs.”. Genome Biology 22 (1): 41.

Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy.

Publication: Journal Article

Mugoni, Vera, Riccardo Panella, Giulia Cheloni, Ming Chen, Olga Pozdnyakova, Dina Stroopinsky, Jlenia Guarnerio, et al. 2019. “Vulnerabilities in MIDH2 AML Confer Sensitivity to APL-Like Targeted Combination Therapy.”. Cell Research 29 (6): 446-59.

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

Publication: Journal Article

Chen, Ming, Lixin Wan, Jiangwen Zhang, Jinfang Zhang, Lourdes Mendez, John G Clohessy, Kelsey Berry, et al. 2018. “Deregulated PP1α Phosphatase Activity towards MAPK Activation Is Antagonized by a Tumor Suppressive Failsafe Mechanism.”. Nature Communications 9 (1): 159.

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Publication: Journal Article

Tan, Justin L, Rachel D Fogley, Ryan A Flynn, Julien Ablain, Song Yang, Violaine Saint-André, Zi Peng Fan, et al. 2016. “Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.”. Molecular Cell 62 (1): 34-46.

Mouse hospital and co-clinical trial project–from bench to bedside.

Publication: Journal Article

Clohessy, John G, and Pier Paolo Pandolfi. 2015. “Mouse Hospital and Co-Clinical Trial Project–from Bench to Bedside.”. Nature Reviews. Clinical Oncology 12 (8): 491-8.

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis.

Publication: Journal Article

Lunardi, Andrea, Kaitlyn A Webster, Antonella Papa, Bhavik Padmani, John G Clohessy, Roderick T Bronson, and Pier Paolo Pandolfi. 2014. “Role of Aberrant PI3K Pathway Activation in Gallbladder Tumorigenesis.”. Oncotarget 5 (4): 894-900.

Infrastructure needs for translational integration of mouse and human trials.

Publication: Journal Article

Clohessy, John G, and Elisa de Stanchina. 2013. “Infrastructure Needs for Translational Integration of Mouse and Human Trials.”. Cold Spring Harbor Protocols 2013 (12): 1109-14.

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Publication: Journal Article

Lunardi, Andrea, Ugo Ala, Mirjam T Epping, Leonardo Salmena, John G Clohessy, Kaitlyn A Webster, Guocan Wang, et al. 2013. “A Co-Clinical Approach Identifies Mechanisms and Potential Therapies for Androgen Deprivation Resistance in Prostate Cancer.”. Nature Genetics 45 (7): 747-55.