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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

Publication: Journal Article

Alimonti, Andrea, Caterina Nardella, Zhenbang Chen, John G Clohessy, Arkaitz Carracedo, Lloyd C Trotman, Ke Cheng, et al. 2010. “A Novel Type of Cellular Senescence That Can Be Enhanced in Mouse Models and Human Tumor Xenografts to Suppress Prostate Tumorigenesis.”. The Journal of Clinical Investigation 120 (3): 681-93.

The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.

Publication: Journal Article

Cheng, K, S Grisendi, J G Clohessy, S Majid, R Bernardi, P Sportoletti, and P P Pandolfi. 2007. “The Leukemia-Associated Cytoplasmic Nucleophosmin Mutant Is an Oncogene With Paradoxical Functions: Arf Inactivation and Induction of Cellular Senescence.”. Oncogene 26 (53): 7391-400.

Vaccine-Educated T cells and a CD123 Bispecific T-Cell Engager for Treatment of Acute Myeloid Leukemia.

Publication: Journal Article

Liegel, Jessica, Dina Stroopinsky, Giulia Cheloni, Dimitra Karagkouni, Myrna Nahas, Yuling Ma, Daniela Torres, et al. 2025. “Vaccine-Educated T Cells and a CD123 Bispecific T-Cell Engager for Treatment of Acute Myeloid Leukemia.”. Blood Advances.

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Providing Expertise in Design and Implementation of Pre-clinical Trials in Mouse Models This facility will work as a resource specializing in preclinical testing in GEMs (genetically engineered mouse models) for investigators with preliminary evidence that an agent or a combination of drugs may...

Preclinical Murine Pharmacogenetics Core

Preclinical Murine Pharmacogenetics Core at BIDMC