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Wen Fan Hu, MD, PhD

Person: Ophthalmology Resident, Class of 2020

Career Plans: Uveitis Fellowship, Moran Eye Center, University of Utah, Salt Lake City, UT Dr. Wen Hu graduated magna cum laude from Yale University in 2008 with a BS with distinction in Molecular Biophysics and Biochemistry, and was inducted into the Phi Beta Kappa honor society. She earned her MD...

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes

Publication: Journal Article

Boucher, Jeremie, Marika Charalambous, Kim Zarse, Marcelo Mori, Andre Kleinridders, Michael Ristow, Anne Ferguson-Smith, and Ronald Kahn. 2014. “Insulin and Insulin-Like Growth Factor 1 Receptors Are Required for Normal Expression of Imprinted Genes”. Proc Natl Acad Sci U S A 111 (40): 14512-7.

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Publication: Journal Article

Lu, Mingjian, Min Wan, Karla Leavens, Qingwei Chu, Bobby Monks, Sully Fernandez, Rexford Ahima, Kohjiro Ueki, Ronald Kahn, and Morris Birnbaum. 2012. “Insulin Regulates Liver Metabolism in Vivo in the Absence of Hepatic Akt and Foxo1”. Nat Med 18 (3): 388-95.

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

Publication: Journal Article

Ussar, Siegfried, Nicholas Griffin, Olivier Bezy, Shiho Fujisaka, Sara Vienberg, Samir Softic, Luxue Deng, Lynn Bry, Jeffrey Gordon, and Ronald Kahn. 2015. “Interactions Between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome”. Cell Metab 22 (3): 516-30.

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

Publication: Journal Article

Vernochet, Cecile, Arnaud Mourier, Olivier Bezy, Yazmin Macotela, Jeremie Boucher, Matthew Rardin, Ding An, et al. 2012. “Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice Against Obesity and Insulin Resistance”. Cell Metab 16 (6): 765-76.

Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD

Publication: Journal Article

Softic, Samir, Jeremie Boucher, Marie Solheim, Shiho Fujisaka, Max-Felix Haering, Erica Homan, Jonathon Winnay, Antonio Perez-Atayde, and Ronald Kahn. 2016. “Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD”. Diabetes 65 (8): 2187-200.

A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species

Publication: Journal Article

Xu, Cong, Mohammadsharif Tabebordbar, Salvatore Iovino, Christie Ciarlo, Jingxia Liu, Alessandra Castiglioni, Emily Price, et al. 2013. “A Zebrafish Embryo Culture System Defines Factors That Promote Vertebrate Myogenesis across Species”. Cell 155 (4): 909-21.

Research

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The Kahn Lab is investigating the mechanism of insulin action and its alterations in insulin resistant states, including type 2 diabetes, obesity and metabolic syndrome. There are 3 major areas of research: 1) Insulin action and insulin resistance. In this area we have projects focusing on the...

Insulin action - Mechanisms of insulin resistance

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Differential signaling by insulin and IGF-1 receptors Differences in downstream signaling (IRS proteins/PI 3-kinase) Signaling by unoccupied insulin receptor Cellular and whole animal analysis using KO and KI mice Signaling in unusual tissues, e.g. the gut and brain

Prof C. Ronald Kahn

Person: Professor at Harvard Medical School

C. Ronald Kahn is a world recognized expert in diabetes and obesity research, as well as a preeminent investigator in the area of insulin signal transduction and mechanisms of altered signaling in diabetes and metabolic disease. Dr. Kahn is Senior Investigator, Head of the Section on Integrative...