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The pleiotropic role of non-coding genes in development and cancer.

Publication: Journal Article

Pasut, Alessandra, Akinobu Matsumoto, John G Clohessy, and Pier Paolo Pandolfi. 2016. “The Pleiotropic Role of Non-Coding Genes in Development and Cancer.”. Current Opinion in Cell Biology 43: 104-13.

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

Publication: Journal Article

Rau, Rachel, Daniel Magoon, Sarah Greenblatt, Li Li, Colleen Annesley, Amy S Duffield, David Huso, et al. 2014. “NPMc+ Cooperates With Flt3/ITD Mutations to Cause Acute Leukemia Recapitulating Human Disease.”. Experimental Hematology 42 (2): 101-13.e5.

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.

Publication: Journal Article

Fagoonee, Sharmila, Claudia Bearzi, Ferdinando Di Cunto, John G Clohessy, Roberto Rizzi, Markus Reschke, Emanuela Tolosano, et al. 2013. “The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells.”. PloS One 8 (8): e72300.

Subtle variations in Pten dose determine cancer susceptibility.

Publication: Journal Article

Alimonti, Andrea, Arkaitz Carracedo, John G Clohessy, Lloyd C Trotman, Caterina Nardella, Ainara Egia, Leonardo Salmena, et al. 2010. “Subtle Variations in Pten Dose Determine Cancer Susceptibility.”. Nature Genetics 42 (5): 454-8.

Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer.

Publication: Journal Article

Montanaro, L, M Brigotti, J Clohessy, S Barbieri, C Ceccarelli, D Santini, M Taffurelli, et al. 2006. “Dyskerin Expression Influences the Level of Ribosomal RNA Pseudo-Uridylation and Telomerase RNA Component in Human Breast Cancer.”. The Journal of Pathology 210 (1): 10-8.

From Mouse to Human: History

Page

APL as a Novel Paradigm for Experimental Therapeutics Acute promyelocytic leukemia (APL) is associated with the accumulation in the bone marrow of tumor cells with promyelocytic features and the invariable association with specific reciprocal chromosomal translocations involving the retinoic acid...

Delivery Unit from Precision RNA Medicine Core Powers New RNA-Based Cancer Therapy

News: May 05, 2025

In a recent Nature Communications study, Dr. Annalisa Di Ruscio and team introduced aptaDiR, a novel RNA therapeutic engineered to silence DNMT1 and reverse abnormal DNA methylation in cancer. Delivered via lipid nanoparticles, aptaDiR reactivated tumor-suppressor genes and significantly reduced...

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Search results

The pleiotropic role of non-coding genes in development and cancer.

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.

Subtle variations in Pten dose determine cancer susceptibility.

Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer.

From Mouse to Human: History

Delivery Unit from Precision RNA Medicine Core Powers New RNA-Based Cancer Therapy

Prescription Patterns for GLP-1 Receptor Agonists and SGLT2 Inhibitors by Physicians' Years in Practice

Advancing Health Equity in the Cardiovascular Device Life Cycle

Statins for Primary Prevention of Cardiovascular Disease-Reply