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The integration of multi-omics data sets can help to unravel the underlying mechanisms across multiple omic layers. We will leverage multi-omics data to profile the heterogeneity of pathways contributing to PD. Our unique study design combining clinical and neuropathological data with genomics...

We have successfully identified multiple novel genetic associations between AD and common and rare variants in endolysosomal genes ( PLD3, RAB10, GRN12, TMEM106B, CPAMD8, MS4A4A). Recently, we performed a systematic, comprehensive evaluation of the contribution of coding variants in each...

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