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The Structural Biology Core Facility at Beth Israel Deaconess Medical Center, located at 99 Brookline Avenue (Research North), was established to provide state-of-the-art support for investigators across BIDMC, Harvard Medical School, and the broader biotechnology and pharmaceutical communities. Our...

Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.

Publication: Journal Article

Chen, Yan Q, Ye Yang, Eugene Y Zhen, Thomas P Beyer, Hongxia Li, Yi Wen, Mariam Ehsani, et al. 2024. “Carboxyl-Terminal Sequences in APOA5 Are Important for Suppressing ANGPTL3/8 Activity.”. Proceedings of the National Academy of Sciences of the United States of America 121 (17): e2322332121.

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.

Publication: Journal Article

Burak, Furkan, Karen E Inouye, Ariel White, Alexandra Lee, Gurol Tuncman, Ediz S Calay, Motohiro Sekiya, et al. 2015. “Development of a Therapeutic Monoclonal Antibody That Targets Secreted Fatty Acid-Binding Protein AP2 to Treat Type 2 Diabetes.”. Science Translational Medicine 7 (319): 319ra205.

Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA.

Publication: Journal Article

Choy, Wing W, Drishadwatti Datta, Catherine A Geiger, Gabriel Birrane, and Marianne A Grant. 2014. “Crystallization and Preliminary X-Ray Analysis of a Complex of the FOXO1 and Ets1 DNA-Binding Domains and DNA.”. Acta Crystallographica. Section F, Structural Biology Communications 70 (Pt 1): 44-8.

Crystal structure of the BARD1 BRCT domains.

Publication: Journal Article

Birrane, Gabriel, Ashok K Varma, Aditi Soni, and John A A Ladias. 2007. “Crystal Structure of the BARD1 BRCT Domains.”. Biochemistry 46 (26): 7706-12.

Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.

Publication: Journal Article

Baek, Kyuwon, Raymond S Brown, Gabriel Birrane, and John A A Ladias. 2007. “Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-Dependent Kinase 9.”. Journal of Molecular Biology 366 (2): 563-73.

Structural Biology Core

The Structural Biology Core Facility at BIDMC, Our core specializes in the expression, purification, and characterization of high-quality proteins for use in structural biology—including Cryo-Electron Microscopy and X-ray Crystallography—as well as a wide range of biochemical, biophysical, and therapeutic development applications.

Jerome Groopman, MD

Person: Scientific Advisor of Structural Biology Core, Dina and Raphael Recanati Professor of Medicine, Harvard Medical School

The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.

Publication: Journal Article

Song, Wenxin, Anne P Beigneux, Thomas A Weston, Kai Chen, Ye Yang, Le Phuong Nguyen, Paul Guagliardo, et al. 2023. “The Lipoprotein Lipase That Is Shuttled into Capillaries by GPIHBP1 Enters the Glycocalyx Where It Mediates Lipoprotein Processing.”. Proceedings of the National Academy of Sciences of the United States of America 120 (44): e2313825120.

Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen.

Publication: Journal Article

Yang, Ye, Anne P Beigneux, Wenxin Song, Le Phuong Nguyen, Hyesoo Jung, Yiping Tu, Thomas A Weston, et al. 2023. “Hypertriglyceridemia in Apoa5-/- Mice Results from Reduced Amounts of Lipoprotein Lipase in the Capillary Lumen.”. The Journal of Clinical Investigation 133 (23).