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Equipment and Technologies
Our facility is equipped with a comprehensive suite of modern instruments supporting the full pipeline—from protein expression and purification to crystallography, biophysical characterization, and advanced structural determination: Protein Expression & Cell Culture Eppendorf S41i CO₂ Shaker...
Community
The Structural Biology Core Facility at BIDMC has served the scientific community for more than 18 years, supporting academic laboratories, startups, and global pharmaceutical partners from early concept through successful execution. We foster a collaborative and interdisciplinary environment by...
Nancy Breslin
Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species.
Nguyen, Le Phuong, Wenxin Song, Ye Yang, Anh P Tran, Thomas A Weston, Hyesoo Jung, Yiping Tu, et al. 2024. “Distinct Strategies for Intravascular Triglyceride Metabolism in Hearts of Mammals and Lower Vertebrate Species.”. JCI Insight 9 (20).
Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells.
Song, Wenxin, Anne P Beigneux, Anne-Marie L Winther, Kristian K Kristensen, Anne L Grønnemose, Ye Yang, Yiping Tu, et al. 2022. “Electrostatic Sheathing of Lipoprotein Lipase Is Essential for Its Movement across Capillary Endothelial Cells.”. The Journal of Clinical Investigation 132 (5).
Lymphocyte-specific protein 1 (LSP1) regulates bone marrow stromal cell antigen 2 (BST-2)-mediated intracellular trafficking of HIV-1 in dendritic cells.
Kulkarni, Rutuja, Shuxian Jiang, Gabriel Birrane, and Anil Prasad. 2020. “Lymphocyte-Specific Protein 1 (LSP1) Regulates Bone Marrow Stromal Cell Antigen 2 (BST-2)-Mediated Intracellular Trafficking of HIV-1 in Dendritic Cells.”. FEBS Letters 594 (12): 1947-59.
Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B.
Birrane, Gabriel, Anne-Laure Dassier, Alla Romashko, Dianna Lundberg, Kevin Holmes, Thomas Cottle, Angela W Norton, Bohong Zhang, Michael F Concino, and Muthuraman Meiyappan. 2019. “Structural Characterization of the α-N-Acetylglucosaminidase, a Key Enzyme in the Pathogenesis of Sanfilippo Syndrome B.”. Journal of Structural Biology 205 (3): 65-71.
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.
Birrane, Gabriel, Anne P Beigneux, Brian Dwyer, Bettina Strack-Logue, Kristian Kølby Kristensen, Omar L Francone, Loren G Fong, et al. 2019. “Structure of the Lipoprotein Lipase-GPIHBP1 Complex That Mediates Plasma Triglyceride Hydrolysis.”. Proceedings of the National Academy of Sciences of the United States of America 116 (5): 1723-32.
NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.
Sharma, Alok K, Gabriel Birrane, Clemens Anklin, Alan C Rigby, and Seth L Alper. 2017. “NMR Insight into Myosin-Binding Subunit Coiled-Coil Structure Reveals Binding Interface With Protein Kinase G-Iα Leucine Zipper in Vascular Function.”. The Journal of Biological Chemistry 292 (17): 7052-65.