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Frankie Heyward identifies IRF3 as a key mediator of the acute hunger-suppressing effects of leptin in AgRP neurons

News: May 31, 2024

Frankie Heyward’s paper was just published in Nature Communications. Frankie used cell-type specific profiling of gene expression and chromatin state in AgRP neurons to predict novel transcriptional mediators of leptin action. Surprisingly, his data suggested that IRF3 might work downstream of...

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Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

Publication: Journal Article

Mayer, Bryan T., Lily Zhang, Allan C. deCamp-, -Michel Nussenzweig, Kathryn E. Stephenson, Boris Julg-, and -Huub C. Gelderblom. 2024. “Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People Without HIV”. Pharmaceutics 16.

Ndidi Owunna, BSc

Person: Clinical Research Assistant

Hometown: Monroe Township, New Jersey Education/background: Bachelor of Science (BS) in Neuroscience from Northeastern University Years in the lab: 1.5 yrs Currently working on recruiting and enrolling participants in our clinical studies. Favorite hobbies/interests outside of work: Some of my...

Mitochondrial DNA mutations in Parkinson's disease brain

Publication: Journal Article

Simon, David K, Joanne Clark Matott, Janaina Espinosa, and Neeta A Abraham. 2017. “Mitochondrial DNA Mutations in Parkinson’s Disease Brain”. Acta Neuropathol Commun.

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.

Publication: Journal Article

Luo, Yang, Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto, Kotaro Ogawa, et al. 2021. “A High-Resolution HLA Reference Panel Capturing Global Population Diversity Enables Multi-Ancestry Fine-Mapping in HIV Host Response.”. Nature Genetics 53 (10): 1504-16.

A composite sleep and pulmonary phenotype predicting hypertension.

Publication: Journal Article

Li, Ruitong, Michael Rueschman, Daniel J Gottlieb, Susan Redline, and Tamar Sofer. 2021. “A Composite Sleep and Pulmonary Phenotype Predicting Hypertension.”. EBioMedicine 68: 103433.

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.

Publication: Journal Article

Kasela, Silva, Victor E Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, et al. 2021. “Genetic and Non-Genetic Factors Affecting the Expression of COVID-19-Relevant Genes in the Large Airway Epithelium.”. Genome Medicine 13 (1): 66.