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Charlie Savage

Person: Undergraduate Research Student

Charlie Savage is an undergraduate pursuing a B.S. in Biochemistry at Boston College. He is an aspiring medical student with strong familial and community ties to diabetes. In my spare time, he enjoys weightlifting, skiing, and spending time in nature, whether by hiking, walking my dog, or sitting...

Thermogenesis: beta-adrenergic agonist activation

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Male C57Bl/6J mice housed at thermoneutrality were administered the β-adrenergic agonist CL 316,243, and changes in oxygen consumption were continuously measured.

Physical activity

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Physical activity was monitored by infrared beam breaks in the Promethion indirect calorimeter for one hour in either a mouse with ad libitum access to food or shortly after food removal. (Rubio et al Mol Metabolism 2023)

Leadership & Staff

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Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold

Publication: Journal Article

Mikhalchenko, Aleksei, June K. Corrigan, Yuchen He, Zalan Peterfi, Alexander S. Banks, and Vadim N. Gladyshev. Submitted. “Comparative Analysis of Naked Mole-Rat Thermogenesis and Its Potential to Maintain Euthermia in Response to Cold”. BioRxiv, Submitted.

Xiaohui Li, PhD

Person: Postdoc Research Fellow

Xiaohui studies the crosstalk among metabolism, epigenetic mechanisms, and DNA damage response. She brings extensive experience in imaging, biochemistry, and in vitro neuronal culture systems. Xiaohui's project focuses on the epigenetic mechanism in breast cancer and glioma. Ph.D. : University of...

Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity.

Publication: Journal Article

Munroe, Melissa E, Kendra Young, Rufei Lu, Joel M Guthridge, Diane L Kamen, Gary S Gilkeson, Michael H Weisman, et al. 2025. “Dysregulated Soluble Immune Mediators and Lupus-Associated Autoantibody Specificities Inform the Development of Immune Indexes That Characterise Classified SLE Transition and SLE Disease Activity.”. Lupus Science & Medicine 12 (2).

IL-17+/IL-10+ Ratio in TCRαβ+ CD4- CD8- T Cells As a Marker of Disease Activity in Lupus-Prone Mice and Patients With Systemic Lupus Erythematosus.

Publication: Journal Article

Imai, Rui, Yi Li, Hao Li, Anwesha Kar, Rong Fu, Wei Li, Vasileios C Kyttaris, and George C Tsokos. 2025. “IL-17+/IL-10+ Ratio in TCRαβ+ CD4- CD8- T Cells As a Marker of Disease Activity in Lupus-Prone Mice and Patients With Systemic Lupus Erythematosus.”. ACR Open Rheumatology 7 (10): e70108.

Interleukin-23 receptor deficiency in podocytes averts the development of lupus nephritis.

Publication: Journal Article

Fu, Rong, Afroditi Boulougoura, Shuilian Yu, Hao Li, Wenliang Pan, Yushiro Endo, Rhea Bhargava, et al. 2025. “Interleukin-23 Receptor Deficiency in Podocytes Averts the Development of Lupus Nephritis.”. Arthritis & Rheumatology (Hoboken, N.J.).

ADAM9 Promotes Glycolysis in Th17 Cells and Autoimmunity Through Activation of IGF-1 Signaling.

Publication: Journal Article

Karino, Kohei, Masataka Umeda, Theodoros Vichos, Wenliang Pan, Michihito Kono, Maria G Tsokos, and George C Tsokos. 2025. “ADAM9 Promotes Glycolysis in Th17 Cells and Autoimmunity Through Activation of IGF-1 Signaling.”. Arthritis & Rheumatology (Hoboken, N.J.).