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Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFβ1 Axis.

Publication: Journal Article

Prete, Alessandro, Agnes S Lo, Peter M Sadow, Swati S Bhasin, Zeus A Antonello, Danica M Vodopivec, Soumya Ullas, et al. 2018. “Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFβ1 Axis.”. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 24 (23): 6078-97.

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Publication: Journal Article

Duquette, Mark, Peter M Sadow, Amjad Husain, Jennifer N Sims, Zeus A Antonello, Andrew H Fischer, Chen Song, et al. 2015. “Metastasis-Associated MCL1 and P16 Copy Number Alterations Dictate Resistance to Vemurafenib in a BRAFV600E Patient-Derived Papillary Thyroid Carcinoma Preclinical Model.”. Oncotarget 6 (40): 42445-67.

Expression of angiogenic switch, cachexia and inflammation factors at the crossroad in undifferentiated thyroid carcinoma with BRAF(V600E).

Publication: Journal Article

Husain, Amjad, Nina Hu, Peter M Sadow, and Carmelo Nucera. 2016. “Expression of Angiogenic Switch, Cachexia and Inflammation Factors at the Crossroad in Undifferentiated Thyroid Carcinoma With BRAF(V600E).”. Cancer Letters 380 (2): 577-85.

Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules.

Publication: Journal Article

Mekel, Michal, Carmelo Nucera, Richard A Hodin, and Sareh Parangi. 2010. “Surgical Implications of B-RafV600E Mutation in Fine-Needle Aspiration of Thyroid Nodules.”. American Journal of Surgery 200 (1): 136-43.

B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.

Publication: Journal Article

Nucera, Carmelo, Alessandro Porrello, Zeus Andrea Antonello, Michal Mekel, Matthew A Nehs, Thomas J Giordano, Damien Gerald, et al. 2010. “B-Raf(V600E) and Thrombospondin-1 Promote Thyroid Cancer Progression.”. Proceedings of the National Academy of Sciences of the United States of America 107 (23): 10649-54.

The landscape of somatic copy-number alteration across human cancers.

Publication: Journal Article

Beroukhim, Rameen, Craig H Mermel, Dale Porter, Guo Wei, Soumya Raychaudhuri, Jerry Donovan, Jordi Barretina, et al. 2010. “The Landscape of Somatic Copy-Number Alteration across Human Cancers.”. Nature 463 (7283): 899-905.

Alessandro Prete, MD, PhD

Person: Postdoc Research Fellow

Lydia Moss

Person: Administrative Assistant

Research

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Our lab is developing independent research program in the CVBR at the BIDMC/HMS, focused on preclinical models of human thyroid cancer with an emphasis on mechanisms of metastatic networks, new models of in vitro angiogenesis, tumor microenvironment, and metabolic regulations, using and dissecting...