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RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology.

Publication: Journal Article

Lei, Hetian, Cynthia Qian, Jinghu Lei, Luis Haddock, Shizuo Mukai, and Andrius Kazlauskas. 2015. “RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology.”. Mol Cell Biol 35 (10): 1673-85.

Nanoparticle-mediated expression of a wnt pathway inhibitor ameliorates ocular neovascularization.

Publication: Journal Article

Wang, Zhongxiao, Rui Cheng, Kyungwon Lee, Puneet Tyagi, Lexi Ding, Uday Kompella, Jing Chen, Xun Xu, and Jian-Xing Ma. 2015. “Nanoparticle-Mediated Expression of a Wnt Pathway Inhibitor Ameliorates Ocular Neovascularization.”. Arterioscler Thromb Vasc Biol 35 (4): 855-64.

ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration.

Publication: Journal Article

Zandi, Souska, Shintaro Nakao, Kwang-Hoon Chun, Paolo Fiorina, Dawei Sun, Ryoichi Arita, Ming Zhao, et al. 2015. “ROCK-Isoform-Specific Polarization of Macrophages Associated With Age-Related Macular Degeneration.”. Cell Rep 10 (7): 1173-86.

Expanding the phenotypic spectrum and variability of endocrine abnormalities associated with TUBB3 E410K syndrome.

Publication: Journal Article

Balasubramanian, Ravikumar, Sheena Chew, Sarah MacKinnon, Peter Kang, Caroline Andrews, Wai-Man Chan, and Elizabeth Engle. 2015. “Expanding the Phenotypic Spectrum and Variability of Endocrine Abnormalities Associated With TUBB3 E410K Syndrome.”. J Clin Endocrinol Metab 100 (3): E473-7.

Serum-free and xenobiotic-free preservation of cultured human limbal epithelial cells.

Publication: Journal Article

Utheim, Oeygunn, Rakibul Islam, Torstein Lyberg, Borghild Roald, Jon Roger Eidet, Maria Fideliz Paz, Darlene A. Dartt, Sten Raeder, and Tor Paaske Utheim. 2015. “Serum-Free and Xenobiotic-Free Preservation of Cultured Human Limbal Epithelial Cells.”. PLoS One 10 (3): e0118517.

RNA-Seq: Improving Our Understanding of Retinal Biology and Disease.

Publication: Journal Article

Farkas, Michael, Elizabeth Au, Maria Sousa, and Eric Pierce. 2015. “RNA-Seq: Improving Our Understanding of Retinal Biology and Disease.”. Cold Spring Harb Perspect Med.

Insulin-like Growth Factor 1 (IGF-1) Stabilizes Nascent Blood Vessels.

Publication: Journal Article

Jacobo, Sarah Melissa, and Andrius Kazlauskas. 2015. “Insulin-Like Growth Factor 1 (IGF-1) Stabilizes Nascent Blood Vessels.”. J Biol Chem 290 (10): 6349-60.

Fueling a Revolution in Retinal Care

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In the 1990s, the 2014 Champalimaud Award Laureates worked in parallel and in collaboration to identify vascular endothelial growth factor (VEGF) as the major trigger for angiogenesis in the eye. In 1993, they showed that the human retina synthesizes VEGF, and subsequently demonstrated that VEGF...

2014 Antonio Champalimaud Vision Award

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2014 António Champalimaud Laureates: Joan W. Miller, MD, FARVO, Evangelos S. Gragoudas, MD, Patricia A. D’Amore, PhD, MBA, FARVO, Lloyd Paul Aiello, MD, PhD, George L. King, MD, Anthony P. Adamis, MD; and Napoleone Ferrara, MD Dear Colleagues, In September, several Mass. Eye and Ear/Harvard Medical...

Comparing Diabetic Macular Edema Treatments

News: February 19, 2015

Results of the DRCR.net Protocol T Study In the first clinical trial directly comparing three drugs most commonly used to treat diabetic macular edema, researchers found all were effective in improving vision and preventing vision loss. However, one drug, aflibercept, provided greater improvement...