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Modification of glycoproteins by N-acetylglucosaminyltransferase V is greatly influenced by accessibility of the enzyme to oligosaccharide acceptors.

Publication: Journal Article

Do, Fregien, Pierce, and Cummings. 1994. “Modification of Glycoproteins by N-Acetylglucosaminyltransferase V Is Greatly Influenced by Accessibility of the Enzyme to Oligosaccharide Acceptors.”. J Biol Chem 269 (38): 23456-64.

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.

Publication: Journal Article

Fu, Jianxin, Holger Gerhardt, Michael McDaniel, Baoyun Xia, Xiaowei Liu, Lacramioara Ivanciu, Annelii Ny, et al. 2008. “Endothelial Cell O-Glycan Deficiency Causes Blood/Lymphatic Misconnections and Consequent Fatty Liver Disease in Mice.”. J Clin Invest 118 (11): 3725-37.

A novel alpha1,2-fucosyltransferase (CE2FT-2) in Caenorhabditis elegans generates H-type 3 glycan structures.

Publication: Journal Article

Zheng, Qinlong, Irma Die, and Richard Cummings. 2008. “A Novel Alpha1,2-Fucosyltransferase (CE2FT-2) in Caenorhabditis Elegans Generates H-Type 3 Glycan Structures.”. Glycobiology 18 (4): 290-302.

Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens.

Publication: Journal Article

Stowell, Sean, Connie Arthur, Padmaja Mehta, Kristen Slanina, Ola Blixt, Hakon Leffler, David Smith, and Richard Cummings. 2008. “Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens.”. J Biol Chem 283 (15): 10109-23.

Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface.

Publication: Journal Article

Carlsson, Susanne, Christopher Oberg, Michael Carlsson, Anders Sundin, Ulf Nilsson, David Smith, Richard Cummings, Jenny Almkvist, Anna Karlsson, and Hakon Leffler. 2007. “Affinity of Galectin-8 and Its Carbohydrate Recognition Domains for Ligands in Solution and at the Cell Surface.”. Glycobiology 17 (6): 663-76.

Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues.

Publication: Journal Article

Marková, Vladimíra, Karel Smetana, Gabriela Jeníková, Jitka Láchová, Veronika Krejciríková, Martin Poplstein, Milan Fábry, et al. 2006. “Role of the Carbohydrate Recognition Domains of Mouse Galectin-4 in Oligosaccharide Binding and Epitope Recognition and Expression of Galectin-4 and Galectin-6 in Mouse Cells and Tissues.”. Int J Mol Med 18 (1): 65-76.

Three New Glaucoma-related Genes Identified

News: January 12, 2016

Janey Wiggs, MD, PhD, is the lead author on the article, “ Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma” published online in Nature Genetics on January 11, 2016. Dr. Wiggs and colleagues at Case Western Reserve University...

Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells.

Publication: Journal Article

Kudelka, Matthew, Aristotelis Antonopoulos, Yingchun Wang, Duc Duong, Xuezheng Song, Nicholas Seyfried, Anne Dell, Stuart Haslam, Richard Cummings, and Tongzhong Ju. 2016. “Cellular O-Glycome Reporter/Amplification to Explore O-Glycans of Living Cells.”. Nat Methods 13 (1): 81-6.

Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†.

Publication: Journal Article

Blackler, Ryan, Dylan Evans, David Smith, Richard Cummings, Cory Brooks, Thomas Braulke, Xinyu Liu, Stephen Evans, and Sven Müller-Loennies. 2016. “Single-Chain Antibody-Fragment M6P-1 Possesses a Mannose 6-Phosphate Monosaccharide-Specific Binding Pocket That Distinguishes N-Glycan Phosphorylation in a Branch-Specific Manner†.”. Glycobiology 26 (2): 181-92.

GlyTouCan 1.0--The international glycan structure repository.

Publication: Journal Article

Aoki-Kinoshita, Kiyoko, Sanjay Agravat, Nobuyuki Aoki, Sena Arpinar, Richard Cummings, Akihiro Fujita, Noriaki Fujita, et al. 2016. “GlyTouCan 1.0--The International Glycan Structure Repository.”. Nucleic Acids Res 44 (D1): D1237-42.