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Bioinformatics and Databases

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Software tools and resources developed by the NCFG: GLAD - a tool to visualize, analyze and compare glycan microarray data for exploratory data analysis. GlycoGlyph - An open source glycan drawing, visualizing and naming application. Allows you to draw glycans in SNFG format and obtain names in CFG...

Institutes

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Where clinicians, researchers, educators, and industry leaders come together to collaborate and discover new life-changing cures. The Harvard Ophthalmology Centers of Excellence and Institutes are multidisciplinary collaborations that unite clinicians, educators, investigators, trainees, and...

Symbol Nomenclature for Graphical Representations of Glycans.

Publication: Journal Article

Varki, Ajit, Richard Cummings, Markus Aebi, Nicole Packer, Peter Seeberger, Jeffrey Esko, Pamela Stanley, et al. 2015. “Symbol Nomenclature for Graphical Representations of Glycans.”. Glycobiology 25 (12): 1323-4.

Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.

Publication: Journal Article

Hu, Liya, Sasirekha Ramani, Rita Czako, Banumathi Sankaran, Ying Yu, David Smith, Richard Cummings, Mary Estes, and Venkataram Prasad. 2015. “Structural Basis of Glycan Specificity in Neonate-Specific Bovine-Human Reassortant Rotavirus.”. Nat Commun 6: 8346.

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis.

Publication: Journal Article

Kooij, Gijs, Rens Braster, Jasper Koning, Lisa Laan, Sandra Vliet, Tamara Los, Anne Marieke Eveleens, et al. 2015. “Trichuris Suis Induces Human Non-Classical Patrolling Monocytes via the Mannose Receptor and PKC: Implications for Multiple Sclerosis.”. Acta Neuropathol Commun 3: 45.

Synthetic 1,2,3-triazole-linked glycoconjugates bind with high affinity to human galectin-3.

Publication: Journal Article

Marchiori, Marcelo Fiori, Dênio Emanuel Pires Souto, Leandro Oliveira Bortot, João Francisco Pereira, Lauro Tatsuo Kubota, Richard Cummings, Marcelo Dias-Baruffi, Ivone Carvalho, and Vanessa Leiria Campo. 2015. “Synthetic 1,2,3-Triazole-Linked Glycoconjugates Bind With High Affinity to Human Galectin-3.”. Bioorg Med Chem 23 (13): 3414-25.

The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites.

Publication: Journal Article

Schneider, Christoph, David Smith, Richard Cummings, Kayluz Frias Boligan, Robert Hamilton, Bruce Bochner, Sylvia Miescher, et al. 2015. “The Human IgG Anti-Carbohydrate Repertoire Exhibits a Universal Architecture and Contains Specificity for Microbial Attachment Sites.”. Sci Transl Med 7 (269): 269ra1.

Deciphering the glycogenome of schistosomes.

Publication: Journal Article

Mickum, Megan, Nina Prasanphanich, Jamie Heimburg-Molinaro, Kristoffer Leon, and Richard Cummings. 2014. “Deciphering the Glycogenome of Schistosomes.”. Front Genet 5: 262.

Identification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individuals.

Publication: Journal Article

Lehoux, Sylvain, Rongjuan Mi, Rajindra Aryal, Yingchun Wang, Katrine Schjoldager, Henrik Clausen, Irma Die, et al. 2014. “Identification of Distinct Glycoforms of IgA1 in Plasma from Patients With Immunoglobulin A (IgA) Nephropathy and Healthy Individuals.”. Mol Cell Proteomics 13 (11): 3097-113.

Investigating virus-glycan interactions using glycan microarrays.

Publication: Journal Article

Smith, David, and Richard Cummings. 2014. “Investigating Virus-Glycan Interactions Using Glycan Microarrays.”. Curr Opin Virol 7: 79-87.