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Investigators
The repeated challenge of insufficient sleep: effects on endothelial function
This project investigated the effects of repeated cycles of short sleep duration on vascular functioning and levels of inflammatory and adhesion molecules in peripheral circulation in healthy participants in order to determine if sleep is essential for homeostasis of multiple host defense mechanisms...
Recent Abstracts
Repeating patterns of sleep restriction and recovery – do we get used to it?
The goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems. We will test whether the hypothalamic-pituitary, sympatho-adrenal...
Heart and Brain Health (CIRCA)
Cerebrovascular Risk, Aging, and Their Effects on the Brain Changes in memory, thinking, and organizational skills occur in the course of normal aging, but can sometimes indicate an underlying disease. These changes in thinking ability can occur as a result of medical conditions (such as high blood...
Core Services
Overview of HDDC Cores and Services Use the links for detailed descriptions, locations and contact information. Biomedical CORE B: Microscopy and Histopathology Histology(paraffin and frozen sections) Electron and Confocal Microscopy Photodocumentation and Widefield Microscopy Advanced Imaging...
Polarized Epithelial Cell Culture
Core Technician: Sierra Anderson Services Polarized epithelial cell lines maintained and available: human intestinal T84, HT29, Caco2-BBe, and SKCO-15; canine renal MDCK I and MDCK II cells; porcine kidney LL-CPK cells Second site storage available for specialized cell lines prepared by HDDC members...
Eye Witness 28 - May 2015
Cover Story Going Viral: Gene Therapy for Ophthalmic Diseases The Grousbeck Gene Therapy Center, directed by Luk H. Vandenberghe, PhD, is a leader in the use of gene therapy to fight blinding diseases. Dr. Vandenberghe’s laboratory, considered the nucleus of the Center, is working to develop safe...
Eye Witness 32 - Nov 2016
Special Issue: Women in Ophthalmology Harvard Ophthalmology women have come a long way since Deborah Pavan-Langston became the first female ophthalmology resident at Harvard. In this special edition of Eye Witness, we celebrate our extraordinary faculty, trainees, and alumni who are leading the...