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Kip Connor, PhD, selected for 2017 Excellence in Mentoring Award from Harvard Medical School

News: March 21, 2017

Kip Connor, PhD, Assistant Professor of Ophthalmology at Harvard Medical School (HMS), was selected for a 2017 Young Mentor Award, which recognizes faculty who are in the early stages of their careers, and are dedicated mentors and educators. This award is one of three Excellence in Mentoring awards...

Endoscopic Surgery of the Sinuses, Eustachian Tube and Ear

Events: Monday, Apr 03, 2017, 03:00am -Wednesday, Apr 05, 2017, 02:00pm

With recent advances in endoscopic treatment of disorders of the sinuses, Eustachian tube, and ear, it is imperative that otolaryngologists are up to date on the latest surgical techniques. The first day of this course will highlight rhinologic topics, including surgery of the skull base, frontal...

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis

Publication: Journal Article

O’Neill, Brian, Hans Lauritzen, Michael Hirshman, Graham Smyth, Laurie Goodyear, and Ronald Kahn. 2015. “Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis”. Cell Rep 11 (8): 1220-35.

PI3-kinase mutation linked to insulin and growth factor resistance in vivo

Publication: Journal Article

Winnay, Jonathon, Marie Solheim, Ercument Dirice, Masaji Sakaguchi, Hye-Lim Noh, Hee Joon Kang, Hirokazu Takahashi, et al. 2016. “PI3-Kinase Mutation Linked to Insulin and Growth Factor Resistance in Vivo”. J Clin Invest 126 (4): 1401-12.

Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells

Publication: Journal Article

Iovino, Salvatore, Alison Burkart, Kristina Kriauciunas, Laura Warren, Katelyn Hughes, Michael Molla, Youn-Kyoung Lee, Mary-Elizabeth Patti, and Ronald Kahn. 2014. “Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human IPS Cells”. Diabetes 63 (12): 4130-42.

Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor

Publication: Journal Article

Ussar, Siegfried, Max-Felix Haering, Shiho Fujisaka, Dominik Lutter, Kevin Lee, Ning Li, Georg Gerber, Lynn Bry, and C. Ronald Kahn. 2017. “Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor”. Diabetes.

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Publication: Journal Article

O’Neill, Brian, Kevin Lee, Katherine Klaus, Samir Softic, Megan Krumpoch, Joachim Fentz, Kristin Stanford, et al. 2016. “Insulin and IGF-1 Receptors Regulate FoxO-Mediated Signaling in Muscle Proteostasis”. J Clin Invest 126 (9): 3433-46.

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

Publication: Journal Article

Kleinridders, Andre, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William Collins, Sara Vienberg, Emmanuel Pothos, and Ronald Kahn. 2015. “Insulin Resistance in Brain Alters Dopamine Turnover and Causes Behavioral Disorders”. Proc Natl Acad Sci U S A 112 (11): 3463-8.

Insulin signaling and environment

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Microbiome as an environmental modifier of insulin resistance Mitochondrial metabolism, sirtuins, metabolism, aging and stress resistance Fructose and high fat diet as modifiers of metabolic syndrome Modeling insulin resistance and diabetes with human iPS cells Role of miRNAs in insulin action and...

Members

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Current & Past Members Andreea-Lucia Stancu [Research Assistant] Korsuk Sirinukunwattana [Postdoctoral Fellow] Michela Tufts [Research Assistant] Michael Pyle [Research Assistant] Suzanne Wetstein [Visiting PhD candidate from Eindhoven University of Technology] Qing Cheng [Research Assistant]...