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Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Publication: Journal Article

O’Neill, Brian, Kevin Lee, Katherine Klaus, Samir Softic, Megan Krumpoch, Joachim Fentz, Kristin Stanford, et al. 2016. “Insulin and IGF-1 Receptors Regulate FoxO-Mediated Signaling in Muscle Proteostasis”. J Clin Invest 126 (9): 3433-46.

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

Publication: Journal Article

Kleinridders, Andre, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William Collins, Sara Vienberg, Emmanuel Pothos, and Ronald Kahn. 2015. “Insulin Resistance in Brain Alters Dopamine Turnover and Causes Behavioral Disorders”. Proc Natl Acad Sci U S A 112 (11): 3463-8.

Insulin signaling and environment

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Microbiome as an environmental modifier of insulin resistance Mitochondrial metabolism, sirtuins, metabolism, aging and stress resistance Fructose and high fat diet as modifiers of metabolic syndrome Modeling insulin resistance and diabetes with human iPS cells Role of miRNAs in insulin action and...

The molecular basis of breast cancer pathological phenotypes

Publication: Journal Article

Heng, Yujing, Susan Lester, Gary Tse, Rachel Factor, Kimberly Allison, Laura Collins, Yunn-Yi Chen, et al. 2017. “The Molecular Basis of Breast Cancer Pathological Phenotypes”. J Pathol 241 (3): 375-91.

Alcohol consumption and breast tumor gene expression

Publication: Journal Article

Wang, Jun, Yujing Heng, Heather Eliassen, Rulla Tamimi, Aditi Hazra, Vincent Carey, Christine Ambrosone, et al. 2017. “Alcohol Consumption and Breast Tumor Gene Expression”. Breast Cancer Res 19 (1): 108.

Achievements by 2016 Summer Intern, Venkat

News: January 04, 2017

Venkat had a Summer Internship with Dr Heng in 2016. His project led him to become a Siemens Foundation 2016 SemiFinalist and today, Venkat is named as a Regeneron STS 2017 Scholar! Great job and congratulations, Venkat!

Siemens Foundation National Finals 2017

News: December 05, 2017

Congratulations to Katherine for reaching the 2017 Siemens Foundation National Finals - whose project is tied for third place. What an amazing achievement!

About the Team

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Our translational medicine team integrates various types of data (clinical, epidemiological, pathology, genomics, proteomics etc.) to 1) investigate risk factors for breast cancer, 2) discover molecular biomarkers or signatures that can be translated into clinically-relevant modalities, and 3)...

Members

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Current & Past Members Andreea-Lucia Stancu [Research Assistant] Korsuk Sirinukunwattana [Postdoctoral Fellow] Michela Tufts [Research Assistant] Michael Pyle [Research Assistant] Suzanne Wetstein [Visiting PhD candidate from Eindhoven University of Technology] Qing Cheng [Research Assistant]...