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Despite the fact that cancer is a disease caused by genetic abnormalities, the most widely accepted means of diagnosing and characterizing cancer cells is with H&E stained microscopic imaging. The identifying features of cancer include abnormally large and crowded cell nuclei with altered cellular...

R01 CA228029 (PI: Perelman)Spectro-Holographic Instrument for Dynamic Sensing of Cancer ProgressionProject Dates: 2018 - 2023Budget: $3.5M R01 CA205431 (PI: Perelman)Isolation and Assessment of Blood-Circulating Cancer Exosomes with LSS and SERS Lab on a Chip Optical Spectroscopic InstrumentProject...

The Center for Advanced Biomedical Imaging and Photonics studies the interaction of light with biological tissue on the microscopic and macroscopic scale. Scientists at the Center work at the interface of biophotonics, bioengineering and cancer biology, with a particular emphasis on: · scattering of...

The enormous increase of Raman signal in the vicinity of metal nanoparticles allows surface-enhanced Raman spectroscopy (SERS) to be employed for label-free detection of substances at extremely low concentrations. However, the ultimate potential of label-free SERS to identify pharmaceutical...

From astronomy to cell biology, the manner in which light propagates in turbid media has been of central importance for many decades. The theory of radiative transfer is widely used to treat this problem by considering the transport of light energy through a random medium and neglecting the wave...

The purpose of this program is to develop optical systems that can perform rapid optical scanning and multispectral imaging of the entire epithelial surface of various organs in the in the human digestive system and present a diagnosis in near real time. This approach should be vastly superior to...