Search

Search results

18 results found

UK Biobank clonal hematopoiesis paper published in Nature

News: July 11, 2018

Our work on mosaic chromosomal alterations in the UK Biobank N=150K interim release has been published in Nature! This study used long-range haplotype phasing information to detect mosaicism in blood at very low clonal fractions (down to ~1%), producing an atlas of 8,342 mosaic events. The...

Mixed-model association for biobank-scale datasets

Publication: Journal Article

Loh, Po-Ru, Gleb Kichaev, Steven Gazal, Armin Schoech, and Alkes Price. 2018. “Mixed-Model Association for Biobank-Scale Datasets”. Nat Genet 50 (7): 906-8.

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Publication: Journal Article

Reshef, YA, Hilary Finucane, David Kelley, Alexander Gusev, Dylan Kotliar, Jacob Ulirsch, Farhad Hormozdiari, et al. 2018. “Detecting Genome-Wide Directional Effects of Transcription Factor Binding on Polygenic Disease Risk”. Nat Genet 50 (10): 1483-93.

Upcoming talks on phasing and mosaicism

News: October 08, 2018

Po-Ru Loh will be speaking about haplotype phasing and mosaic chromosomal alterations at 23andMe (Thu 10/11), ASHG 2018 (Wed 10/17, platform talk #17 at 9am), and Michigan (Tue 10/23).

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

Publication: Journal Article

Loh, Po-Ru, Giulio Genovese, Robert Handsaker, Hilary Finucane, Yakir A Reshef, Pier Francesco Palamara, Brenda Birmann, et al. 2018. “Insights into Clonal Haematopoiesis from 8,342 Mosaic Chromosomal Alterations”. Nature 559 (7714): 350-55.

Maxwell A. Sherman

Person: Ph.D. Student, MIT Electrical Engineering and Computer Science (EECS), -> Co-Founder & CTO, Serinus Biosciences

Max is a PhD student in Electrical Engineering and Computer Science (EECS) at MIT. He previously studied applied mathematics at Brown University and theoretical statistics at the University of Cambridge before working as a scientific programmer in Peter Park's computational genomics group at Harvard...

Max Sherman has joined the lab!

News: August 14, 2018

Max is starting a PhD program at MIT EECS and is interested in how population patterns learned from biobank data can be used to predict traits, diseases and health outcomes for individuals. Welcome, Max!

Highlights

Page

Selected Preprints Mukamel RE*, Handsaker RE*, Sherman MA, Barton AR, Hujoel MLA, McCarroll SA**, Loh PR**. Repeat polymorphisms in non-coding DNA underlie top genetic risk loci for glaucoma and colorectal cancer. medRxiv (2022). [ pdf + supp] Selected Publications Hujoel MLA, Sherman MA, Barton AR...