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Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.

Xie, Liang, Michael B Duncan, Jessica Pahler, Hikaru Sugimoto, Margot Martino, Julie Lively, Thomas Mundel, et al. 2011. “Counterbalancing Angiogenic Regulatory Factors Control the Rate of Cancer Progression and Survival in a Stage-Specific Manner.”. Proceedings of the National Academy of Sciences of the United States of America 108 (24): 9939-44.

Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.

Niu, Qi, Carole Perruzzi, Daniel Voskas, Jack Lawler, Daniel J Dumont, and Laura E Benjamin. 2004. “Inhibition of Tie-2 Signaling Induces Endothelial Cell Apoptosis, Decreases Akt Signaling, and Induces Endothelial Cell Expression of the Endogenous Anti-Angiogenic Molecule, Thrombospondin-1.”. Cancer Biology & Therapy 3 (4): 402-5.