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Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.

Publication: Journal Article

Eroglu, Cagla, Nicola J Allen, Michael W Susman, Nancy A O’Rourke, Chan Young Park, Engin Ozkan, Chandrani Chakraborty, et al. 2009. “Gabapentin Receptor Alpha2delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis.”. Cell 139 (2): 380-92.

Structures of thrombospondins.

Publication: Journal Article

Carlson, C B, J Lawler, and D F Mosher. 2008. “Structures of Thrombospondins.”. Cellular and Molecular Life Sciences : CMLS 65 (5): 672-86.

Halofuginone inhibits tumor growth in the polyoma middle T antigen mouse via a thrombospondin-1 independent mechanism.

Publication: Journal Article

Yee, Karen O, Caitlin M Connolly, Mark Pines, and Jack Lawler. 2006. “Halofuginone Inhibits Tumor Growth in the Polyoma Middle T Antigen Mouse via a Thrombospondin-1 Independent Mechanism.”. Cancer Biology & Therapy 5 (2): 218-24.

Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor.

Publication: Journal Article

Isenberg, Scott, Maria J Calzada, Longen Zhou, Nenghua Guo, Jack Lawler, Xue-Qing Wang, William A Frazier, and David D Roberts. 2005. “Endogenous Thrombospondin-1 Is Not Necessary for Proliferation But Is Permissive for Vascular Smooth Muscle Cell Responses to Platelet-Derived Growth Factor.”. Matrix Biology : Journal of the International Society for Matrix Biology 24 (2): 110-23.

Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins.

Publication: Journal Article

Short, Sarah M, Alexandrine Derrien, Radha P Narsimhan, Jack Lawler, Donald E Ingber, and Bruce R Zetter. 2005. “Inhibition of Endothelial Cell Migration by Thrombospondin-1 Type-1 Repeats Is Mediated by Beta1 Integrins.”. The Journal of Cell Biology 168 (4): 643-53.

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The Freedman Lab, a component of the Musculoskeletal Translation Innovation Initiative (MTII) at BIDMC, has a primary focus on pioneering innovative solutions to address unmet clinical needs within the musculoskeletal (MSK) domain. Our capabilities encompass a range of disciplines including...