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Selective Pharmacological Inhibition of NOX2 by GSK2795039 Improves Bladder Dysfunction in Cyclophosphamide-Induced Cystitis in Mice.

de Oliveira, Mariana G, Fabíola Z Monica, Gabriela R Passos, Jamaira A Victorio, Ana Paula Davel, Anna Lethicia Lima Oliveira, Carlos A Parada, Carlos A L D’Ancona, Warren G Hill, and Edson Antunes. 2022. “Selective Pharmacological Inhibition of NOX2 by GSK2795039 Improves Bladder Dysfunction in Cyclophosphamide-Induced Cystitis in Mice.”. Antioxidants (Basel, Switzerland) 12 (1).

Mouse Models of Diabetic Bladder Symptoms

Lower urinary tract symptoms (LUTS) including overactive bladder, incontinence and flaccid bladder may be the most common complication for patients with diabetes, affecting up to 80–90% of patients by some estimates. We wanted to know which of the mouse strains with high blood glucose would develop...