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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.

Publication: Journal Article

Patel, Suraj J, Nan Liu, Sam Piaker, Anton Gulko, Maynara L Andrade, Frankie D Heyward, Tyler Sermersheim, et al. 2022. “Hepatic IRF3 Fuels Dysglycemia in Obesity through Direct Regulation of Ppp2r1b.”. Science Translational Medicine 14 (637): eabh3831.

Control of lipolysis by a population of oxytocinergic sympathetic neurons.

Publication: Journal Article

Li, Erwei, Luhong Wang, Daqing Wang, Jingyi Chi, Zeran Lin, Gordon I Smith, Samuel Klein, Paul Cohen, and Evan D Rosen. 2024. “Control of Lipolysis by a Population of Oxytocinergic Sympathetic Neurons.”. Nature 625 (7993): 175-80.

Crosstalk Between Adipose and Lymphatics in Health and Disease.

Publication: Journal Article

Westcott, Gregory P, and Evan D Rosen. 2022. “Crosstalk Between Adipose and Lymphatics in Health and Disease.”. Endocrinology 163 (1).

Regulation of early adipose commitment by Zfp521.

Publication: Journal Article

Kang, Sona, Peter Akerblad, Riku Kiviranta, Rana K Gupta, Shingo Kajimura, Michael J Griffin, Jie Min, Roland Baron, and Evan D Rosen. 2012. “Regulation of Early Adipose Commitment by Zfp521.”. PLoS Biology 10 (11): e1001433.

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Publication: Journal Article

Kong, Xingxing, Alexander Banks, Tiemin Liu, Lawrence Kazak, Rajesh R Rao, Paul Cohen, Xun Wang, et al. 2014. “IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α.”. Cell 158 (1): 69-83.

Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling.

Publication: Journal Article

Roh, Hyun Cheol, Manju Kumari, Solaema Taleb, Danielle Tenen, Christopher Jacobs, Anna Lyubetskaya, Linus T-Y Tsai, and Evan D Rosen. 2020. “Adipocytes Fail to Maintain Cellular Identity During Obesity Due to Reduced PPARγ Activity and Elevated TGFβ-SMAD Signaling.”. Molecular Metabolism 42: 101086.

Interferon regulatory factors are transcriptional regulators of adipogenesis.

Publication: Journal Article

Eguchi, Jun, Qing-Wu Yan, Dustin E Schones, Michael Kamal, Chung-Hsin Hsu, Michael Q Zhang, Gregory E Crawford, and Evan D Rosen. 2008. “Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis.”. Cell Metabolism 7 (1): 86-94.

The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.

Publication: Journal Article

Ahmad, Rasheed, Areej Al-Roub, Shihab Kochumon, Nadeem Akther, Reeby Thomas, Manju Kumari, Merin S Koshy, et al. 2018. “The Synergy Between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.”. Journal of Immunology (Baltimore, Md. : 1950) 200 (10): 3599-3611.

Inflammation causes insulin resistance via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

Publication: Unpublished

Yan, Shuai, Anna Santoro, Micah J. Niphakis, Antonio M. Pinto, Christopher L. Jacobs, Rasheed Ahmad, Radu M. Suciu, et al. 2023. “Inflammation Causes Insulin Resistance via Interferon Regulatory Factor 3 (IRF3)-Mediated Reduction in FAHFA Levels”. BioRxiv.

Evan Rosen has received the Roy O. Greep Award for Outstanding Research

News: September 20, 2023

Established in 1944, the Endocrine Society’s Laureate Awards recognize the highest achievements in the endocrinology field, including groundbreaking research and innovations in clinical care. The Roy O. Greep Award for Outstanding Research recognizes meritorious contributions to research in...