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5012 results found

Dietary restriction impacts health and lifespan of genetically diverse mice.

Publication: Journal Article

Di Francesco, Andrea, Andrew G Deighan, Lev Litichevskiy, Zhenghao Chen, Alison Luciano, Laura Robinson, Gaven Garland, et al. 2024. “Dietary Restriction Impacts Health and Lifespan of Genetically Diverse Mice.”. Nature 634 (8034): 684-92.

A Spectrum of Age- and Gender-Dependent Lower Urinary Tract Phenotypes in Three Mouse Models of Type 2 Diabetes.

Publication: Journal Article

MacIver, Bryce, Erica M Bien, Mariana G de Oliveira, and Warren G Hill. 2023. “A Spectrum of Age- and Gender-Dependent Lower Urinary Tract Phenotypes in Three Mouse Models of Type 2 Diabetes.”. Metabolites 13 (6).

Aquaporin (AQP) channels in the spiny dogfish, Squalus acanthias I: Characterization of AQP3 and AQP15 function and expression, and localization of the proteins in gill and spiral valve intestine.

Publication: Journal Article

Cutler, Christopher P, Debra Murray, Tolulope Ojo, Sheena Harmon, Bryce MacIver, Gordon Cramb, and Mark L Zeidel. 2022. “Aquaporin (AQP) Channels in the Spiny Dogfish, Squalus Acanthias I: Characterization of AQP3 and AQP15 Function and Expression, and Localization of the Proteins in Gill and Spiral Valve Intestine.”. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology 258: 110702.

Generalists as Clinical Physiologists: Bringing Science Back to the Bedside.

Publication: Journal Article

Ricotta, Daniel N, Andrew J Hale, Jason A Freed, Tara E Scribner, Mark L Zeidel, and Shoshana J Herzig. 2021. “Generalists As Clinical Physiologists: Bringing Science Back to the Bedside.”. Journal of General Internal Medicine 36 (12): 3847-51.

Micturition video thermography in awake, behaving mice.

Publication: Journal Article

Verstegen, Anne M, Margaret M Tish, Luca P Szczepanik, Mark L Zeidel, and Joel C Geerling. 2020. “Micturition Video Thermography in Awake, Behaving Mice.”. Journal of Neuroscience Methods 331: 108449.

Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology.

Publication: Journal Article

Chen, Huan, David H Vandorpe, Xiang Xie, Seth L Alper, Mark L Zeidel, and Weiqun Yu. 2020. “Disruption of Cav1.2-Mediated Signaling Is a Pathway for Ketamine-Induced Pathology.”. Nature Communications 11 (1): 4328.

Our Scientific Approach

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Our lab focuses on unraveling the biochemistry and neuropathology underlying this complex neurodegenerative disorder. We take a systems-level approach to investigate the molecular mechanisms driving disease progression, particularly focusing on key protein pathways, including VPS35, USP30, LRRK2...

Methods

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Functional MRI Processing for Mouse Micturition Studies Functional MRI (fMRI) studies in rodents is somewhat uncommon as it requires some cognitive or physiological stimulus that causes measurable changes in brain activity. This project however, lends itself well to fMRI studies as voiding induced...

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