Found in translation of mTOR signaling.
Clohessy, John G, Markus Reschke, and Pier Paolo Pandolfi. 2012. “Found in Translation of MTOR Signaling.”. Cell Research 22 (9): 1315-8.
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Pro-senescence therapy for cancer treatment.
Nardella, Caterina, John G Clohessy, Andrea Alimonti, and Pier Paolo Pandolfi. 2011. “Pro-Senescence Therapy for Cancer Treatment.”. Nature Reviews. Cancer 11 (7): 503-11.
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
Cheng, Ke, Paolo Sportoletti, Keisuke Ito, John G Clohessy, Julie Teruya-Feldstein, Jeffery L Kutok, and Pier Paolo Pandolfi. 2010. “The Cytoplasmic NPM Mutant Induces Myeloproliferation in a Transgenic Mouse Model.”. Blood 115 (16): 3341-5.
Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.
Sportoletti, Paolo, Silvia Grisendi, Samia M Majid, Ke Cheng, John G Clohessy, Agnes Viale, Julie Teruya-Feldstein, and Pier Paolo Pandolfi. 2008. “Npm1 Is a Haploinsufficient Suppressor of Myeloid and Lymphoid Malignancies in the Mouse.”. Blood 111 (7): 3859-62.
In Vitro Target Validation
Target validation of agents or combinations of agents in cell culture in one or more murine and human tumor cell lines or mouse embryonic fibroblasts (MEFs) of various genotypes (see below). Use of several different assays depending upon the agent and type of information sought. Availability of an...
The Tug1 lncRNA locus is essential for male fertility.
Lewandowski, Jordan P, Gabrijela Dumbović, Audrey R Watson, Taeyoung Hwang, Emily Jacobs-Palmer, Nydia Chang, Christian Much, et al. 2020. “The Tug1 LncRNA Locus Is Essential for Male Fertility.”. Genome Biology 21 (1): 237.
Intragenic antagonistic roles of protein and circRNA in tumorigenesis.
Guarnerio, Jlenia, Yang Zhang, Giulia Cheloni, Riccardo Panella, Jesse Mae Katon, Mark Simpson, Akinobu Matsumoto, et al. 2019. “Intragenic Antagonistic Roles of Protein and CircRNA in Tumorigenesis.”. Cell Research 29 (8): 628-40.
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.
Bester, Assaf C, Jonathan D Lee, Alejandro Chavez, Yu-Ru Lee, Daphna Nachmani, Suhani Vora, Joshua Victor, et al. 2018. “An Integrated Genome-Wide CRISPRa Approach to Functionalize LncRNAs in Drug Resistance.”. Cell 173 (3): 649-664.e20.
Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.
Patnaik, Akash, Kenneth D Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P Gehring, Katja Helenius, et al. 2017. “Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.”. Cancer Discovery 7 (7): 750-65.
Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.
van de Ven, Anne L, Shifalika Tangutoori, Paige Baldwin, Ju Qiao, Codi Gharagouzloo, Nina Seitzer, John G Clohessy, et al. 2017. “Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.”. Molecular Cancer Therapeutics 16 (7): 1279-89.