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Beat the Heat

News: May 06, 2025

Are you hoping to stay cool this summer? Learn more (e por Espanol) here/aqui Eligibility: To participate in the study, you must: Not have any air conditioning in your home including central AC, window units, mini splits, etc Aged 55-95 years old Speak Spanish or English Live in Roxbury, East Boston...

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Publication: Journal Article

Tan, Justin L, Rachel D Fogley, Ryan A Flynn, Julien Ablain, Song Yang, Violaine Saint-André, Zi Peng Fan, et al. 2016. “Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.”. Molecular Cell 62 (1): 34-46.

Mouse hospital and co-clinical trial project–from bench to bedside.

Publication: Journal Article

Clohessy, John G, and Pier Paolo Pandolfi. 2015. “Mouse Hospital and Co-Clinical Trial Project–from Bench to Bedside.”. Nature Reviews. Clinical Oncology 12 (8): 491-8.

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis.

Publication: Journal Article

Lunardi, Andrea, Kaitlyn A Webster, Antonella Papa, Bhavik Padmani, John G Clohessy, Roderick T Bronson, and Pier Paolo Pandolfi. 2014. “Role of Aberrant PI3K Pathway Activation in Gallbladder Tumorigenesis.”. Oncotarget 5 (4): 894-900.

Infrastructure needs for translational integration of mouse and human trials.

Publication: Journal Article

Clohessy, John G, and Elisa de Stanchina. 2013. “Infrastructure Needs for Translational Integration of Mouse and Human Trials.”. Cold Spring Harbor Protocols 2013 (12): 1109-14.

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Publication: Journal Article

Lunardi, Andrea, Ugo Ala, Mirjam T Epping, Leonardo Salmena, John G Clohessy, Kaitlyn A Webster, Guocan Wang, et al. 2013. “A Co-Clinical Approach Identifies Mechanisms and Potential Therapies for Androgen Deprivation Resistance in Prostate Cancer.”. Nature Genetics 45 (7): 747-55.

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

Publication: Journal Article

Alimonti, Andrea, Caterina Nardella, Zhenbang Chen, John G Clohessy, Arkaitz Carracedo, Lloyd C Trotman, Ke Cheng, et al. 2010. “A Novel Type of Cellular Senescence That Can Be Enhanced in Mouse Models and Human Tumor Xenografts to Suppress Prostate Tumorigenesis.”. The Journal of Clinical Investigation 120 (3): 681-93.

The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.

Publication: Journal Article

Cheng, K, S Grisendi, J G Clohessy, S Majid, R Bernardi, P Sportoletti, and P P Pandolfi. 2007. “The Leukemia-Associated Cytoplasmic Nucleophosmin Mutant Is an Oncogene With Paradoxical Functions: Arf Inactivation and Induction of Cellular Senescence.”. Oncogene 26 (53): 7391-400.

Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4).

Publication: Journal Article

Sermersheim, Tyler J, LeAnna J Phillips, Parker L Evans, Barbara B Kahn, Steven S Welc, and Carol A Witczak. 2024. “Regulation of Injury-Induced Skeletal Myofiber Regeneration by Glucose Transporter 4 (GLUT4).”. Skeletal Muscle 14 (1): 33.

Jan Heng, PhD

Person: Director of Detection Unit, Assistant Professor of Pathology, Harvard Medical School

Meet Dr. Heng, our director of RNA Detection Unit within the Precision RNA Medicine Core at BIDMC. She is also an Assistant Professor of Pathology at BIDMC. She leads a breast cancer translational research laboratory, aiming to uncover biomarkers with clinical relevance. With academic roots in...