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A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation

Publication: Journal Article

Ouwens, Zon, Pronk, Bos, Möller, Cheatham, Kahn, and Maassen. 1994. “A Mutant Insulin Receptor Induces Formation of a Shc-Growth Factor Receptor Bound Protein 2 (Grb2) Complex and P21ras-GTP Without Detectable Interaction of Insulin Receptor Substrate 1 (IRS1) With Grb2. Evidence for IRS1-Independent P21ras-GTP Formation”. J Biol Chem 269 (52): 33116-22.

Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice

Publication: Journal Article

Ferber, Meyerovitch, Kriauciunas, and Kahn. 1994. “Vanadate Normalizes Hyperglycemia and Phosphoenolpyruvate Carboxykinase MRNA Levels in Ob/Ob Mice”. Metabolism 43 (11): 1346-54.

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

Publication: Journal Article

Kahn. 1994. “Banting Lecture. Insulin Action, Diabetogenes, and the Cause of Type II Diabetes”. Diabetes 43 (8): 1066-84.

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus

Publication: Journal Article

Folli, Saad, Backer, and Kahn. 1993. “Regulation of Phosphatidylinositol 3-Kinase Activity in Liver and Muscle of Animal Models of Insulin-Resistant and Insulin-Deficient Diabetes Mellitus”. J Clin Invest 92 (4): 1787-94.

Two steps of insulin receptor internalization depend on different domains of the beta-subunit

Publication: Journal Article

Carpentier, Paccaud, Backer, Gilbert, Orci, Kahn, and Baecker J [corrected to Backer. 1993. “Two Steps of Insulin Receptor Internalization Depend on Different Domains of the Beta-Subunit”. J Cell Biol 122 (6): 1243-52.

The insulin receptor and its substrate: molecular determinants of early events in insulin action

Publication: Journal Article

Kahn, White, Shoelson, Backer, Araki, Cheatham, Csermely, Folli, Goldstein, and Huertas. 1993. “The Insulin Receptor and Its Substrate: Molecular Determinants of Early Events in Insulin Action”. Recent Prog Horm Res 48: 291-339.

Alterations in insulin receptor and substrate phosphorylation in hypertensive rats

Publication: Journal Article

Kahn, and Saad. 1992. “Alterations in Insulin Receptor and Substrate Phosphorylation in Hypertensive Rats”. J Am Soc Nephrol 3 (4 Suppl): S69-77.

Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro

Publication: Journal Article

Yamada, Goncalves, Kahn, and Shoelson. 1992. “Substitution of the Insulin Receptor Transmembrane Domain With the C-Neu/ErbB2 Transmembrane Domain Constitutively Activates the Insulin Receptor Kinase in Vitro”. J Biol Chem 267 (18): 12452-61.

Effect of phospholipase treatment on insulin receptor signal transduction

Publication: Journal Article

Zoppini, and Kahn. 1992. “Effect of Phospholipase Treatment on Insulin Receptor Signal Transduction”. Diabetologia 35 (2): 109-15.

Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process

Publication: Journal Article

Shoelson, Boni-Schnetzler, Pilch, and Kahn. 1991. “Autophosphorylation Within Insulin Receptor Beta-Subunits Can Occur As an Intramolecular Process”. Biochemistry 30 (31): 7740-6.