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Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.

Hinks, Anne, John Bowes, Joanna E. Cobb, Hannah C. Ainsworth, Miranda C. Marlon, M. E. Comeau, Marc Sudman, et al. 2017. “Fine-Mapping the MHC Locus in Juvenile Idiopathic Arthritis (JIA) Reveals Genetic Heterogeneity Corresponding to Distinct Adult Inflammatory Arthritic Diseases.”. Annals of Rheumatic Diseases 76 (4): 765-72.

Macrophages tailor their function according to the signals found in tissue microenvironments, assuming a wide spectrum of phenotypes. A detailed understanding of macrophage phenotypes in human tissues is limited. Using single-cell RNA sequencing, we defin