Search

Nisl pretium fusce id velit ut tortor pretium viverra suspendisse. Urna porttitor rhoncus dolor purus non enim praesent elementum. Felis donec et odio pellentesque diam volutpat commodo sed. Hic rerum possimus accusamus velit qui alias quia sit ipsa. Aspernatur qui dolores qui quod qui eos quas...

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Mi sit amet mauris commodo quis imperdiet massa. Qui minus repellendus libero non rem perferendis. Consectetur magnam molestiae consequatur qui excepturi. Vero tenetur vel et...

By: Richard D. Cummings While the N-glycosylation sequon N-X-S/T in glycoproteins of plants, fungi, and animals, is well known, there are many reports of alternative sequons for N-glycosylation in animals (1), including the sequences -N-X-C- (2-4), -N-X-V- (5,6), -N-V-E- (7), -N-X-A- (8), -N-X-G- (9...

By: Richard D. Cummings L-Ascorbic acid, vitamin C, is termed a ‘sugar acid’ or ‘acidic sugar’, and is a derivative of glucose with a carboxyl group at C1 (1). In mammals, UDP-glucuronic acid is the source of D-glucuronic acid, the precursor to vitamin C (2). Vitamin C is sometimes referred to as a...

By: Richard D. Cummings Many different monosaccharides from trioses (3-carbon) to decoses (10-carbon) and above are found in nature (1). The most famous nonose (9-carbon) in human glycans is N-acetylneuraminic acid (Neu5Ac) also termed sialic acid. The name sialic acid derives from its discovery in...

By: Richard D. Cummings Sialic acid is a nonose (9-carbon) monosaccharide found in many organisms. All vertebrates have sialic acid, while most invertebrates do not have sialic acid, but there are notable ones that do, as discussed below. In addition, sialic acid is not generated nor found in...

By: Richard D. Cummings The endoplasmic reticulum (ER) of many types of cells contain members of a family of UDP-glucuronosyltransferases (UGTs). These enzymes utilize uridine diphosphate glucuronic acid (UDP-GlcA) as a donor and add GlcA to a tremendous variety of aglycone hydrophobic compounds...

By: Richard D. Cummings The major urinary glycoprotein is the Tamm-Horsfall protein (THP), also named uromodulin (Umod), and encoded by UMOD (1-4). Its concentration in urine can be as high as 1-2 mg/mL. It was discovered in 1950 by Tamm and Horsfall in their studies on compounds in urine that could...

Lectus nulla at volutpat diam ut. Mattis molestie a iaculis at erat pellentesque adipiscing. Felis imperdiet proin fermentum leo vel orci. Malesuada bibendum arcu vitae elementum curabitur. Turpis cursus in hac habitasse platea dictumst quisque sagittis purus. Voluptas quas qui minima id in...

Nisl pretium fusce id velit ut tortor pretium viverra suspendisse. Urna porttitor rhoncus dolor purus non enim praesent elementum. Felis donec et odio pellentesque diam volutpat commodo sed. Hic rerum possimus accusamus velit qui alias quia sit ipsa. Aspernatur qui dolores qui quod qui eos quas...