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Lahey Emergency Department

At the Center for Drug Discovery and Translational Research, BIDMC, Harvard Medical School, Sun Lab offers a platform and expertise in medicinal chemistry to facilitate the translation of research from bench to bedside.
Our laboratory has studied the optimal integration of molecular simulations into the generation of bioactive molecules. In collaboration with investigators at Harvard Medical School, we have applied this research methodology to discover novel immune modulators for the treatment of autoimmune diseases (e.g., Inflammatory Bowel Diseases, Diabetes, etc) and cancers (e.g., Breast cancer). Currently, our interest focuses on Aryl Hydrocarbon Receptor (AHR) modulators, Orai channel blockers, and threonine/serine kinases.

Chemical Biology, Biochemistry, Beth Israel

Clifford Saper, Saper lab at BIDMC, apply cutting edge neuroscience to identify brain circuitry underlying wake-sleep, circadian rhythms, thermoregulation, and how they are affected in human neurodegenerative disorders