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Alison is a PhD candidate in the Harvard Medical School BIG program and is interested in studying the role of human genetic variation and population history in health and disease. Welcome, Alison!

Po-Ru Loh will be presenting work on mosaic CNV detection using long-range phasing at the Broad Institute MIA Seminar on Wed 2/21 (with Giulio Genovese), the MIT Bioinformatics Seminar on Wed 2/21, and the UCLA Computational Genomics Winter Institute on Mon 2/26.

This paper, " Mixed-model association for biobank-scale datasets" (Loh et al. 2018 Nat Genet), explores best practices for genome-wide association analyses in very large cohorts.

Po-Ru Loh will be presenting work on mosaic CNVs in clonal hematopoiesis and brain development at the Harvard Biostatistics / HMS Department of Biomedical Informatics B3D Seminar on Mon 4/30.

Po-Ru Loh has been selected for a 2018 NIH Director's New Innovator Award, which supports "unusually innovative research from early career investigators." The proposed project (" Revealing Somatic Genome Alterations and Their Clinical Sequelae: Ultrasensitive Computational Detection of Mosaic...

Our work on mosaic chromosomal alterations in the UK Biobank N=150K interim release has been published in Nature! This study used long-range haplotype phasing information to detect mosaicism in blood at very low clonal fractions (down to ~1%), producing an atlas of 8,342 mosaic events. The...

Max is starting a PhD program at MIT EECS and is interested in how population patterns learned from biobank data can be used to predict traits, diseases and health outcomes for individuals. Welcome, Max!

Po-Ru Loh will be speaking about haplotype phasing and mosaic chromosomal alterations at 23andMe (Thu 10/11), ASHG 2018 (Wed 10/17, platform talk #17 at 9am), and Michigan (Tue 10/23).