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Scientific Core

The Next-Generation Clinical Research and Data Science Core monitors clinical and research activities of all Center sites, including Massachusetts Eye and Ear Infirmary (MEE), Massachusetts General Hospital (MGH), University of Utah (UofU), and University of California San Francisco (UCSF). The Core...

MD-PhD Track: HEART MD-PhD Summer Program

Harvard/MIT Equitable Access to Research Training (HEART) MD-PhD Summer Program The HEART MD-PhD Summer Program is a specialty track within SHURP focused on students interested in MD-PhD training, founded by current students in Harvard's MD-PhD program. Mission Statement: The HEART MD-PhD Summer...

Eye Witness 42 - Sept 2022

DOWNLOAD FULL ISSUE Inclusion, Diversity, and Equity at Harvard Ophthalmology In the latest issue of Eye Witness, we highlight our latest efforts on inclusion, diversity, and equity, including our EYE CAN program, a multi-tiered framework created by our IDE leaders that aims to increase diversity...

HDDC Seminars 2022-2023

Date Speaker Monday, December 5, 2022 Christopher Burd, MS, PhD. (Yale, CT) Host: Wayne Lencer, MD. Monday, January 9, 2023 Nicholas Zachos, PhD. (Nashville, TN) Host: Jerrold Turner, MD, PhD. Monday, March 6, 2023 Marcia B. Goldberg, MD. (MGH, HMS) Host: Wayne Lencer, MD. Monday, April 3, 2023 Ruth...

Message from the Editor-in-Chief

Dear Colleagues, Research in gene augmentation and genome editing for the treatment of inherited retinal disorders (IRDs) is thriving. It is estimated that IRDs affect about 200,000- 300,000 people in the United States and 4-6 million people worldwide. Most patients with these conditions become...

Gene Therapy, Gene Editing, and IRDs

Gene-Augmentation Therapy Gene therapy typically refers to gene-augmentation therapy. In this approach, a healthy version of the mutated gene is packaged inside an engineered and nonpathogenic form of adeno-associated virus (AAV), with the virus serving as a vector to carry the gene. AAV does not...

Gene Therapy for Other Ophthalmic Conditions

Advances in the future may include viral vectors, non-viral vectors, and delivery methods that allow treatment of a greater retinal expanse and an expanded approach to technical challenges related to gene size and disease mechanisms. Genetic therapies for non-retinal ophthalmic diseases are also...