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Posterior uveitis, or choroiditis, refers to inflammation of the choroid. It can affect the retina and/or optic nerve and lead to permanent loss of vision. What causes posterior uveitis? Posterior uveitis can be infectious or non-infectious. Many non-infectious cases are idiopathic. Common non...

Checkpoint inhibitors are becoming more widely used in the management of cancer, so it is important for the ophthalmologist to examine the medication list carefully in a patient with new-onset uveitis. Uveitis Associated with Immune Checkpoint Inhibitors Immune checkpoint inhibitors are used...

DOWNLOAD FULL ISSUE Education, Research, and Reflection Provide Strong Foundations for Unrivaled Clinical Care In this final installment of our 2020 Vision series, you will read about Harvard Ophthalmology’s 20 years of groundbreaking advances and how they helped to define clinical excellence...

DOWNLOAD FULL ISSUE Inclusion, Diversity, and Equity at Harvard Ophthalmology In the latest issue of Eye Witness, we highlight our latest efforts on inclusion, diversity, and equity, including our EYE CAN program, a multi-tiered framework created by our IDE leaders that aims to increase diversity...

Until the approval of Luxturna®, there were no definitive treatments for any IRDs. Today, with the success of Luxturna®, preliminary results from therapies currently under investigation, and an expanding therapeutic toolkit, we have good reason for optimism. We envision a future in which gene...

Applications to Other Diseases The same types of genetic strategies currently being tested for IRDs are also being tested and beginning to receive regulatory approvals in other areas of medicine. For example, the FDA has approved both gene-augmentation therapy and antisense oligonucleotide therapy...

In this issue of eye Insights, we explore posterior uveitis and its varied etiologies. Inside, you’ll find common causes, tips for diagnosing posterior uveitis, and treatment techniques. Inside Message from Editor-in-Chief What is Posterior Uveitis Diagnosis Treatment Checkpoint Inhibitors Editor-in...

Treatment of Infectious Uveitis Treatment of infectious uveitis is dependent on the specific microbe. Treatment of Non-infectious Uveitis Anti-inflammatories Periocular, intravitreal, or systemic steroids are the mainstay of the acute treatment of non-infectious posterior uveitis. Topical steroids...

Dear Colleagues, Research in gene augmentation and genome editing for the treatment of inherited retinal disorders (IRDs) is thriving. It is estimated that IRDs affect about 200,000- 300,000 people in the United States and 4-6 million people worldwide. Most patients with these conditions become...

Gene-Augmentation Therapy Gene therapy typically refers to gene-augmentation therapy. In this approach, a healthy version of the mutated gene is packaged inside an engineered and nonpathogenic form of adeno-associated virus (AAV), with the virus serving as a vector to carry the gene. AAV does not...