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Dear Colleagues, In this issue of eye Insights, we take a close look at posterior uveitis. Inside, you’ll find techniques and tips for evaluating and managing patients with this condition. Due to its many etiologies, posterior uveitis can be challenging to treat until the cause of the inflammation...

The most common symptoms of posterior uveitis are blurred vision and floaters, and the most common signs are chorioretinal infiltrates and vitreous cells. Posterior uveitis is diagnosed by slit lamp examination and indirect ophthalmoscopy. Imaging modalities, including fundus autofluorescence...

While gene therapy is not yet widely available for inherited retinal disorsers (IRDs), researchers are making exciting discoveries, and the future looks more promising than ever before. In this issue of eye Insights, we provide a look into current offerings in gene therapy, and a glimpse into the...

Inherited retinal disorders are rare, hereditary disorders caused by mutations in genes that encode proteins needed for normal retinal health and function. The first gene associated with retinitis pigmentosa was identified at Mass Eye and Ear in 1990, and since then, over 250 IRD-causing genes have...

The first gene-augmentation therapy for an IRD was approved by the U.S. Food and Drug Administration (FDA) in December 2017 after nearly two decades of development in preclinical models and clinical trials. The drug, known as Luxturna®, is for individuals with autosomal recessive retinal dystrophies...

Posterior uveitis, or choroiditis, refers to inflammation of the choroid. It can affect the retina and/or optic nerve and lead to permanent loss of vision. What causes posterior uveitis? Posterior uveitis can be infectious or non-infectious. Many non-infectious cases are idiopathic. Common non...

Until the approval of Luxturna®, there were no definitive treatments for any IRDs. Today, with the success of Luxturna®, preliminary results from therapies currently under investigation, and an expanding therapeutic toolkit, we have good reason for optimism. We envision a future in which gene...

Applications to Other Diseases The same types of genetic strategies currently being tested for IRDs are also being tested and beginning to receive regulatory approvals in other areas of medicine. For example, the FDA has approved both gene-augmentation therapy and antisense oligonucleotide therapy...

In this issue of eye Insights, we explore posterior uveitis and its varied etiologies. Inside, you’ll find common causes, tips for diagnosing posterior uveitis, and treatment techniques. Inside Message from Editor-in-Chief What is Posterior Uveitis Diagnosis Treatment Checkpoint Inhibitors Editor-in...

Treatment of Infectious Uveitis Treatment of infectious uveitis is dependent on the specific microbe. Treatment of Non-infectious Uveitis Anti-inflammatories Periocular, intravitreal, or systemic steroids are the mainstay of the acute treatment of non-infectious posterior uveitis. Topical steroids...