Menglu Yang, MD, PhD
Harvard Catalyst Profile Mass Eye and Ear Profile
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Isabel Deakins, OD
Profiles Mass Eye and Ear Harvard Catalyst
Levi N. Kanu, MD
Profiles Mass Eye and Ear (clinical) Mass Eye and Ear (research) Harvard Catalyst Profile
Message from the Editor-in-Chief
Dear Colleagues, Research in gene augmentation and genome editing for the treatment of inherited retinal disorders (IRDs) is thriving. It is estimated that IRDs affect about 200,000- 300,000 people in the United States and 4-6 million people worldwide. Most patients with these conditions become...
Gene Therapy, Gene Editing, and IRDs
Gene-Augmentation Therapy Gene therapy typically refers to gene-augmentation therapy. In this approach, a healthy version of the mutated gene is packaged inside an engineered and nonpathogenic form of adeno-associated virus (AAV), with the virus serving as a vector to carry the gene. AAV does not...
Gene Therapy for Other Ophthalmic Conditions
Advances in the future may include viral vectors, non-viral vectors, and delivery methods that allow treatment of a greater retinal expanse and an expanded approach to technical challenges related to gene size and disease mechanisms. Genetic therapies for non-retinal ophthalmic diseases are also...
2022 AUPO Annual Meeting
Harvard Ophthalmology was well represented at the Association of University Professors of Ophthalmology (AUPO) annual meeting last month. Chair Joan W. Miller, MD, the President-elect of AUPO, served as Program Committee Chair for the five-day event. Alice Lorch, MD, MPH, Assistant Professor of...
Leo A. Kim, MD, PhD, Next Incumbent of the Monte J. Wallace Ophthalmology Chair in Retina at Mass Eye and Ear
Leo A. Kim, MD, PhD, a clinician scientist with surgical expertise and an innovator in the treatment of retinal diseases associated with neovascularization and fibrosis and an Associate Professor of Ophthalmology at Harvard Medical School, will serve as the next incumbent of the Monte J. Wallace...
Meredith Gregory-Ksander, PhD, Awarded NIH R01 Grant for Glaucoma Research
The destruction of retinal ganglion cells caused by the type II transmembrane protein Fas ligand (Fasl) is a key factor in glaucoma pathogenesis. Meredith Gregory-Ksander, PhD, Assistant Professor of Ophthalmology and Assistant Scientist at Schepens Eye Research Institute of Mass Eye and Ear, and Co...
Ophthalmology Residents Receive ASCRS Awards
Yanna Bian, MD, a PGY-3 resident, and Sarah Wang, MD, a PGY-4 resident, have been selected as two of the 10 winners of the American Society of Cataract and Refractive Surgery (ASCRS) Foundation 2022 Resident Excellence Award. This award enables ophthalmology residents exhibiting exemplary...